Zhang Zhuo-Zhuo, Huang Dan-Ying, Shi Bing-Feng
School of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, 610106, China.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China.
Org Biomol Chem. 2022 May 26;20(20):4061-4073. doi: 10.1039/d2ob00558a.
In recent years, transition-metal-catalyzed C-H functionalization has gradually developed into a powerful tool for the synthesis of ferrocenes in an atom- and step-economic fashion. However, despite significant achievements, the vast majority of these C-H functionalizations required precious 4d or 5d transition metal catalysts. The use of inexpensive and sustainable 3d metals in the C-H functionalization of ferrocenes remains challenging, especially the development of asymmetric versions. Herein, we summarize the remarkable recent progress in the synthesis of ferrocenes by 3d transition metal-catalyzed C-H activation until December 2021.
近年来，过渡金属催化的C-H官能化反应已逐渐发展成为一种以原子经济性和步骤经济性方式合成二茂铁的强大工具。然而，尽管取得了显著成就，但这些C-H官能化反应绝大多数都需要使用昂贵的4d或5d过渡金属催化剂。在二茂铁的C-H官能化反应中使用廉价且可持续的3d金属仍然具有挑战性，尤其是不对称版本的开发。在此，我们总结了截至2021年12月3d过渡金属催化C-H活化合成二茂铁的最新显著进展。
