Department of Radiology, Mie University, Tsu, Japan.
Department of Pathology and Matrix Biology, Mie University, Tsu, Japan.
Thorac Cancer. 2022 Oct;13(20):2904-2907. doi: 10.1111/1759-7714.14624. Epub 2022 Sep 1.
Radiation-induced lung damage (RILD) is a critical problem in lung cancer radiotherapy, and it is difficult to predict its severity. Although no biomarkers for RILD have been established, tenascin C (TNC) is an extracellular matrix glycoprotein involved in the remodeling of damaged tissues and has been implicated in inflammation and fibrosis. We report the unique case of a 36-year-old man with adenocarcinoma of the lung, Union for International Cancer Control stage IIIB, who was treated with radiotherapy before lung surgery. The surgical specimen showed histopathological expression of TNC in the region where radiation pneumonitis was observed radiographically. Serum TNC levels were elevated after radiotherapy. In this case, TNC is suggested to be implicated in RILD and may be a potential candidate as a biomarker for the onset and severity of the condition.
放射性肺损伤（RILD）是肺癌放疗中的一个关键问题，其严重程度难以预测。尽管尚未确定 RILD 的生物标志物，但 tenascin C（TNC）是一种参与损伤组织重塑的细胞外基质糖蛋白，与炎症和纤维化有关。我们报告了一例独特的病例，一名 36 岁男性，患有肺癌，国际抗癌联盟（Union for International Cancer Control）分期为 IIIB 期，在肺手术前接受了放疗。手术标本显示在放射学观察到放射性肺炎的区域有 TNC 的组织病理学表达。放疗后血清 TNC 水平升高。在这种情况下，TNC 被认为与 RILD 有关，可能是该疾病发病和严重程度的潜在候选生物标志物。
