Department of Neurosurgery, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China.
Department of Neurosurgery, The First People's Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China.
Clin Chim Acta. 2018 Jun;481:69-74. doi: 10.1016/j.cca.2018.02.033. Epub 2018 Feb 27.
Tenascin-C is a matricellular protein related to brain injury. We studied serum tenascin-C in acute intracerebral hemorrhage (ICH) and examined the associations with severity and outcome following the acute event.
Tenascin-C samples were obtained from 162 patients with acute hemorrhagic stroke and 162 healthy controls. Poor 90-day functional outcome was defined as modified Rankin Scale score > 2. Early neurological deterioration (END) and hematoma growth (HG) were recorded at 24 h.
Patients had higher tenascin-C levels than controls. Tenascin-C levels were positively correlated with hematoma volume or National Institutes of Health Stroke Scale score at baseline. Elevated tenascin-C levels were independently associated with END, HG, 90-day mortality and poor functional outcome. Moreover, tenascin-C levels significantly predicted END, HG and 90-day outcomes under receiver operating characteristic curves.
An increase in serum tenascin-C level is associated with an adverse outcome in ICH patients, supporting the potential role of serum tenascin-C as a prognostic biomarker for hemorrhagic stroke.
Tenascin-C 是一种与脑损伤相关的细胞外基质蛋白。我们研究了急性脑出血（ICH）患者血清中的 tenascin-C，并探讨了其与急性事件后严重程度和结局的相关性。
收集了 162 例急性出血性脑卒中患者和 162 例健康对照者的 tenascin-C 样本。90 天功能预后不良定义为改良 Rankin 量表评分＞2 分。在 24 小时记录早期神经功能恶化（END）和血肿扩大（HG）。
患者的 tenascin-C 水平高于对照组。基线时 tenascin-C 水平与血肿体积或国立卫生研究院卒中量表评分呈正相关。升高的 tenascin-C 水平与 END、HG、90 天死亡率和不良功能结局独立相关。此外，受试者工作特征曲线下 tenascin-C 水平显著预测 END、HG 和 90 天结局。
血清 tenascin-C 水平升高与 ICH 患者不良结局相关，支持血清 tenascin-C 作为出血性脑卒中预后生物标志物的潜在作用。
