Lehrer M, Gold M S
Adv Alcohol Subst Abuse. 1986 Winter;6(2):123-41. doi: 10.1300/J251v06n02_09.
The clinical diagnosis of cocaine abuse is more difficult than previously recognized. The laboratory can play an important role in helping identify cocaine abusers and also in monitoring the progress of their recovery. An overview of the role of the laboratory is presented with the goal of optimizing the clinician's ability to apply available technology in an efficient manner. Various chromatographic and competitive binding techniques for the detection of cocaine and its metabolites in biological fluids are discussed and limits of each technique is identified. The cases of false negative and false positive results are explored and an approach to maximize benefits and economics of testing is described.
可卡因滥用的临床诊断比以往认为的更加困难。实验室在帮助识别可卡因滥用者以及监测他们的康复进程方面可以发挥重要作用。本文概述了实验室的作用，目的是优化临床医生有效应用现有技术的能力。讨论了用于检测生物体液中可卡因及其代谢物的各种色谱和竞争性结合技术，并确定了每种技术的局限性。探讨了假阴性和假阳性结果的情况，并描述了一种使检测效益和经济性最大化的方法。
