Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695, USA.
Chem Commun (Camb). 2022 Sep 20;58(75):10568-10571. doi: 10.1039/d2cc04013a.
Bioconjugation of carbohydrates has been a challenging task because of their chemical, functional, and structural diversities, and no single chemical modification tool can be universally applicable to all the target substrates in different environments. In this report, we have developed a bioconjugation strategy for labeling of carbohydrate derivatives through a phosphine-mediated three-component coupling reaction in an ionic liquid medium.
糖的生物共轭由于其化学、功能和结构的多样性一直是一项具有挑战性的任务，并且没有单一的化学修饰工具可以普遍适用于不同环境中的所有目标底物。在本报告中，我们开发了一种通过在离子液体介质中进行膦介导的三组分偶联反应来标记糖衍生物的生物共轭策略。
