Shahvelayati Ashraf S, Ghazvini Maryam, Yadollahzadeh Khadijeh, Delbari Akram S
Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran.
Department of Chemistry, Payame Noor University, P.O. Box, 19395-4697, Tehran, Iran.
Comb Chem High Throughput Screen. 2018;21(1):14-18. doi: 10.2174/1386207321666180124094536.
The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. In recent years, the use of ionic liquids as a green media for organic synthesis has become a chief study area. This is due to their unique properties such as non-volatility, non-flammability, chemical and thermal stability, immiscibility with both organic compounds and water and recyclability. Ionic liquids are used as environmentally friendly solvents instead of hazardous organic solvents.
We report the condensation reaction between α-oximinoketone and dialkyl acetylene dicarboxylate in the presence of triphenylphosphine to afford substituted pyrroles under ionic liquid conditions in good yields.
Densely functionalized pyrroles was easily prepared from reaction of α-oximinoketones, dialkyl acetylene dicarboxylate in the presence of triphenylphosphine in a quantitative yield under ionic liquid conditions at room temperature.
In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time, having easily available-recyclable ionic liquids, and good to high yields are advantages of present method.
在特定任务离子液体（ILs）存在下进行多组分反应（MCRs）的发展，离子液体不仅用作环境友好的反应介质，还用作催化剂，是一种符合可持续化学要求的新方法。近年来，将离子液体用作有机合成的绿色介质已成为主要研究领域。这是由于它们具有诸如不挥发性、不可燃性、化学和热稳定性、与有机化合物和水均不混溶以及可回收性等独特性质。离子液体被用作环境友好型溶剂以替代有害的有机溶剂。
我们报道了在离子液体条件下，α-肟基酮与二烷基乙炔二羧酸酯在三苯基膦存在下发生缩合反应，以良好产率得到取代吡咯。
在离子液体条件下，于室温下，α-肟基酮、二烷基乙炔二羧酸酯在三苯基膦存在下反应，能以定量产率轻松制备出功能化密集的吡咯。
总之，离子液体被证明是用于选择性合成功能化吡咯的一种有用且新颖的反应介质。这种反应介质可替代有害有机溶剂的使用。后处理简便、多官能团化合物的合成、反应时间缩短、离子液体易于获得且可回收以及产率良好至高是本方法的优点。
