García M S, Barañao R I, Fernández O, Bordenave H, Rumi L S
Allergol Immunopathol (Madr). 1987 Jan-Feb;15(1):15-8.
Circulating immune complexes (CIC) levels were evaluated in two groups of cancerous patients to try to correlate CIC levels, tumor stage and chemotherapy received. There were 40 patients with Lung Cancer (LC) clinical stages III and IV; 60 patients with Breast Cancer (BC) stages II, III and IV and 38 normal controls. LC patients showed significant increase in CIC values before, during and after treatment as compared to controls, without any difference among groups under different treatment combinations and tumor stage. Stage II BC patients showed decreased CIC levels during treatment (p less than 0.01 vs initial value). This decrease was maintained after treatment (p less than 0.02). Stage III BC patients showed different behaviour according to treatment: those who only received chemotherapy (ADM + CTX) showed no significant differences during treatment, and those treated with ADM + CTX and megestol acetate (MA) displayed decreased CIC levels after treatment (p less than 0.05) reaching similar control values. Stage IV patients treated with ADM + CTX + MA returned to normal CIC values during treatment. These results proved that combined treatment of chemotherapy and hormone therapy diminished CIC levels in BC patients, while therapy given to LC patients did not present any modifications.
对两组癌症患者的循环免疫复合物（CIC）水平进行评估，以尝试将CIC水平、肿瘤分期和所接受的化疗联系起来。其中有40例肺癌（LC）临床III期和IV期患者；60例乳腺癌（BC）II期、III期和IV期患者以及38例正常对照者。与对照组相比，LC患者在治疗前、治疗期间和治疗后的CIC值显著升高，不同治疗组合和肿瘤分期的组间无差异。II期BC患者在治疗期间CIC水平降低（与初始值相比，p<0.01）。治疗后该降低仍持续存在（p<0.02）。III期BC患者根据治疗方式表现出不同的情况：仅接受化疗（阿霉素+环磷酰胺）的患者在治疗期间无显著差异，而接受阿霉素+环磷酰胺和醋酸甲地孕酮（MA）治疗的患者在治疗后CIC水平降低（p<0.05），达到与对照组相似的值。接受阿霉素+环磷酰胺+MA治疗的IV期患者在治疗期间CIC值恢复正常。这些结果证明，化疗和激素联合治疗可降低BC患者的CIC水平，而给予LC患者的治疗未出现任何变化。
