Neri B, Comparini T, Ciatto S, Cataliotti L, Distante V, Bartalucci S
Cancer Detect Prev. 1985;8(1-2):53-6.
We report on the possible diagnostic and prognostic role of circulating immune complexes (CIC) determination in breast cancer. A sensitivity of 87% and a specificity of 90% were observed in a case-control study of 15 cancers and 25 noncancer healthy controls. A direct correlation of CIC level to the presence and probably to the entity of the tumor mass was assessed by comparing preoperative to postoperative CIC determinations in cancer cases: CIC levels were significantly lower after tumor removal. These preliminary results suggest further studies on the use of CIC determination in the follow-up of breast cancer for the early diagnosis of recurrent disease.
我们报告了循环免疫复合物（CIC）测定在乳腺癌中可能的诊断和预后作用。在一项针对15例癌症患者和25例非癌症健康对照的病例对照研究中，观察到其敏感性为87%，特异性为90%。通过比较癌症病例术前和术后的CIC测定结果，评估了CIC水平与肿瘤肿块的存在以及可能与肿瘤实体的直接相关性：肿瘤切除后CIC水平显著降低。这些初步结果表明，需要进一步研究将CIC测定用于乳腺癌随访以早期诊断复发性疾病。
