Choo Donghyeok, Kim Sung-Soo, Kwon Danbee, Lee Kichang, Yoon Hakyoung
VIP Animal Medical Center, Seongbuk-gu, Seoul, Republic of Korea.
Bundang Leaders Animal Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea.
Vet Radiol Ultrasound. 2023 Jan;64(1):140-148. doi: 10.1111/vru.13154. Epub 2022 Sep 1.
The renal cortical thickness (RCT) has been correlated with renal function. Previous studies have also reported that the RCT:Abdominal aorta(Ao) ratio is constant in normal dogs with various physical factors. This multi-center, retrospective, analytical study aimed to determine if there are differences between actual RCT and predicted value of RCT considering physical factors in dogs with acute or chronic renal disease. We also aimed to demonstrate whether the RCT and Ao ratio index would be useful for evaluating renal pathology. A total of 54 dogs with acute or chronic renal disease and 30 normal healthy dogs were included in this study. The RCT was measured at the center of the renal pyramid as the shortest distance perpendicular to the renal capsule from the base of the renal medullary pyramid at three points. The diameter of the Ao was measured just caudal to the branch of the left renal artery in the sagittal plane in systole. The RCT:Ao ratio of chronic kidney disease (CKD) patients was 0.50 ± 0.11 (mean ± standard deviation). The RCT:Ao ratio in normal dogs was 0.67 ± 0.07. The RCT:Ao ratio in patients with acute kidney injury (AKI) was 0.83 ± 0.05. There was a statistically significant difference between normal dogs and dogs with CKD (P < 0.001) and between normal dogs and dogs with AKI (P < 0.001). In conclusion, findings from the current study supported using the RCT:Ao ratio as a non-invasive quantitative method for characterizing kidney pathology in dogs with acute or chronic renal disease.
肾皮质厚度（RCT）与肾功能相关。先前的研究还报告称，在具有各种身体因素的正常犬中，RCT与腹主动脉（Ao）的比值是恒定的。这项多中心、回顾性分析研究旨在确定在患有急性或慢性肾病的犬中，考虑身体因素时，实际RCT与RCT预测值之间是否存在差异。我们还旨在证明RCT与Ao比值指数是否有助于评估肾脏病理。本研究共纳入了54只患有急性或慢性肾病的犬和30只正常健康犬。RCT在肾锥体中心测量，即从肾髓质锥体底部到肾包膜的最短垂直距离，在三个点进行测量。Ao的直径在收缩期矢状面中左肾动脉分支的尾侧进行测量。慢性肾病（CKD）患者的RCT与Ao比值为0.50±0.11（平均值±标准差）。正常犬的RCT与Ao比值为0.67±0.07。急性肾损伤（AKI）患者的RCT与Ao比值为0.83±0.05。正常犬与CKD犬之间（P<0.001）以及正常犬与AKI犬之间（P<0.001）存在统计学显著差异。总之，本研究结果支持将RCT与Ao比值作为一种非侵入性定量方法，用于表征患有急性或慢性肾病的犬的肾脏病理。
