Department of Medicine, University of Mauritius, 80837 Réduit, Mauritius; Biomaterials, Drug Delivery and Nanotechnology Unit, Center for Biomedical and Biomaterials Research, University of Mauritius, 80837 Réduit, Mauritius.
Department of Plastic and Reconstructive Surgery, Bedford Hospital NHS Trust, Kempston Road, Bedford, MK42 FDJ, United Kingdom.
Foot (Edinb). 2022 Sep;52:101909. doi: 10.1016/j.foot.2022.101909. Epub 2022 Feb 4.
Diabetic foot ulcer is a preventable complication of diabetes that imposes a significant burden on the community. It leads to amputation and increased disability if left untreated and thus bears profound implications on the individual, the community and the health system at large. Diabetic foot (DF) is an area of research interest where interdisciplinary researchers are trying to elucidate the best strategy to halt the progression of chronic diabetic wounds. It is an area where tissue engineering research is making a strong impact through the use of scaffolds and skin substitutes for diabetic wound healing. This review aims at discussing the geographical health economics, its impact on healing and factors influencing financial costs of DFU. The upcoming economic and clinical impacts due to disease outbreak such as the 2020 COVID-19 has also been discussed. Finally, it will discuss novel therapy available with emphasis on skin tissue engineering scaffolds with a cost-benefit analysis. The review aims at promoting better management of people with diabetes with emphasis on emerging treatments and technologies.
糖尿病足溃疡是糖尿病可预防的并发症之一，给社区带来了巨大负担。如果不加以治疗，它会导致截肢和残疾增加，从而对个人、社区和整个卫生系统产生深远影响。糖尿病足（DF）是一个研究热点领域，跨学科研究人员正在努力阐明阻止慢性糖尿病伤口进展的最佳策略。在这个领域，组织工程研究通过使用支架和皮肤替代品来促进糖尿病伤口愈合，产生了重大影响。本综述旨在讨论地理卫生经济学及其对愈合的影响，以及影响糖尿病足溃疡（DFU）经济成本的因素。还讨论了由于 2020 年 COVID-19 等疾病爆发而即将产生的经济和临床影响。最后，它将讨论现有的新型疗法，重点是皮肤组织工程支架，并进行成本效益分析。该综述旨在通过强调新兴治疗方法和技术，促进更好地管理糖尿病患者。
