Nagarajan Prithiviraj, Prithiviraj Rajalaksmi, Patil Sharangouda J, Krishna Suresh Babu Naidu, Naidoo Vasanthrie
Department of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, 607403, India.
Department of Ophthalmology, Sri Manakula Vinayagar Medical College, and Hospital, Kalitheerthal kuppam, Madagadipet, Puducherry, 605 107, India.
Curr Stem Cell Res Ther. 2025;20(5):509-523. doi: 10.2174/011574888X334166240921120502.
This study investigates the therapeutic potential of adipose-derived stem cells (ASCs) in diabetic foot ulcers (DFUs). The goal is to further research regenerative medicine by improving knowledge of ASC-based therapies in diabetic wound management. A comprehensive literature review included studies from reputable databases, including PubMed and the Cochrane Library. We paid particular attention to the clinical, , and investigations of the utility and effectiveness of ASCs in treating DFU. We also highlighted novel isolation techniques and application methods for ASCs in chronic wound management. ASCs have shown great potential in regenerative interventions for diabetes, especially in DFU management. These cells facilitate wound repair by differentiating into different cell types, promoting angiogenesis, secreting growth factors, reducing inflammation, and increasing wound perfusion. However, the current body of research on ASC applications for DFU still requires further investigation. This shows the importance of thoroughly studying their biological mechanisms and therapeutic uses. This review establishes that ASC-based treatments effectively enhance outcomes for patients suffering from DFU. We recommend further investigation of the functionality of ASCs and therapeutic approaches to maximize their therapeutic potential in managing diabetic wounds, thereby advancing the development of regenerative medicine.
本研究调查了脂肪来源干细胞（ASC）在糖尿病足溃疡（DFU）中的治疗潜力。目标是通过增进对基于ASC的疗法在糖尿病伤口管理方面的了解，进一步研究再生医学。全面的文献综述纳入了来自知名数据库（包括PubMed和Cochrane图书馆）的研究。我们特别关注了ASC在治疗DFU中的实用性和有效性的临床、 以及 研究。我们还强调了ASC在慢性伤口管理中的新型分离技术和应用方法。ASC在糖尿病的再生干预中已显示出巨大潜力，尤其是在DFU管理方面。这些细胞通过分化为不同细胞类型、促进血管生成、分泌生长因子、减轻炎症和增加伤口灌注来促进伤口修复。然而，目前关于ASC应用于DFU的研究仍需进一步调查。这表明深入研究其生物学机制和治疗用途的重要性。本综述证实，基于ASC的治疗可有效改善DFU患者的治疗效果。我们建议进一步研究ASC的功能和治疗方法，以最大限度地发挥其在管理糖尿病伤口方面的治疗潜力，从而推动再生医学的发展。
