南海柳珊瑚 Subergorgia suberosa 中五个新的亚砜嘌呤杂合体 Subergorgines A-E，它们是亚砜酮嘌呤类的混合物。

Subergorgines A-E, five new suberosanone-purine hybrids from the South China Sea gorgonian Subergorgia suberosa.

机构信息

Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, People's Republic of China; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.

出版信息

Bioorg Chem. 2022 Nov;128:106040. doi: 10.1016/j.bioorg.2022.106040. Epub 2022 Jul 26.

DOI:10.1016/j.bioorg.2022.106040

PMID:36049320

Abstract

Five new suberosanone-purine hybrids, namely subergorgines A-E (1-5), were isolated from the South China Sea gorgonian Subergorgia suberosa. Their structures were elucidated on the basis of extensive spectroscopic data and the absolute configurations were clarified by the theoretical ECD calculation. Compounds 1-5 were rare purine alkaloids merged with the same suberosanone moiety via different C (6)-N bridges. Cytotoxic activities of the isolates were tested. Compound 4 was found to be the most active against the HL-60 cancer cell line with an IC value of 14.3 μM. A plausible biosynthetic pathway for suberosanone-purine hybrids was also discussed.

摘要

从南海柳珊瑚 Subergorgia suberosa 中分离得到了 5 种新型的亚砜嘌呤杂合体，分别为 subergorgines A-E（1-5）。基于广泛的光谱数据阐明了它们的结构，并通过理论ECD 计算确定了它们的绝对构型。化合物 1-5 是罕见的嘌呤生物碱，通过不同的 C（6）-N 桥与相同的亚砜酮部分结合。对分离得到的化合物进行了细胞毒性测试。发现化合物 4 对 HL-60 癌细胞系的活性最强，IC 值为 14.3 μM。还讨论了亚砜酮-嘌呤杂合体的可能生物合成途径。