来自中国南海柳珊瑚亚速尔软柳珊瑚的嘌呤和嘧啶衍生物。

Purine and pyrimidine derivatives from the South China Sea gorgonian Subergorgia suberosa.

作者信息

Qi Shu-Hua, Zhang Si, Gao Cheng-Hai, Li Qin-Xing

机构信息

Key Laboratory of Marine Bio-Resourses Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, Guangzhou, Guangdong, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2008 Jul;56(7):993-4. doi: 10.1248/cpb.56.993.

DOI:10.1248/cpb.56.993

PMID:18591817

Abstract

Three new purine derivatives, namely, 4-caryboxy-5,6-dihydro-4H,8H-pyrimido[1,2,3-cd]purine-8,10(9H)-dione (1), 7,9-dihydro-1-(3-oxobutyl)-1H-purine-6,8-dione (2), and 7-hydro-9-(3-oxobutyl)-1H-purine-6,8-dione (3) together with six known purine and pyrimidine derivatives were isolated from the EtOH/CH(2)Cl(2) extracts of the South China Sea gorgonian Subergorgia suberosa. The structures of 1-3 were determined on the bases of extensive spectroscopic analysis, including 1D and 2D NMR data.

摘要

从中国南海柳珊瑚扁柳珊瑚（Subergorgia suberosa）的乙醇/二氯甲烷提取物中分离出三种新的嘌呤衍生物，即4-羧基-5,6-二氢-4H,8H-嘧啶并[1,2,3-cd]嘌呤-8,10(9H)-二酮（1）、7,9-二氢-1-(3-氧代丁基)-1H-嘌呤-6,8-二酮（2）和7-氢-9-(3-氧代丁基)-1H-嘌呤-6,8-二酮（3），以及六种已知的嘌呤和嘧啶衍生物。通过广泛的光谱分析，包括一维和二维核磁共振数据，确定了1-3的结构。