Department of Ophthalmology, Medical University of Graz, Graz, Austria.
Division of Haematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Ophthalmic Res. 2023;66(1):164-169. doi: 10.1159/000526874. Epub 2022 Sep 1.
A recent study suggested that non-O blood groups had an increased risk for the presence of retinal vein occlusion (RVO). In this study, we investigated (i) an association between blood group and the presence of RVO and (ii) whether this association correlated to other RVO risk factors.
We included 485 RVO patients and 295 control subjects who were recruited in this case-control study. We determined ABO genotypes rs8176719 as a marker for the O allele and rs8176746 for the B allele by polymerase chain reaction.
We did not find an association between ABO blood group and the presence of RVO. In detail, the proportion of ABO blood groups was similar among RVO patients and control subjects (p = 0.527). In a logistic regression, non-O blood group was associated with 1.06-fold higher odds of being a RVO patient (95% CI: 0.78-1.45, p = 0.693), and this lack of association prevailed upon multivariable adjustment for age, gender, history of stroke and venous thromboembolism, and co-medication with lipid-lowering agents.
Although non-O blood groups are a known risk factor for thrombotic and cardiovascular disease, they do not seem to be a major risk factor for the development of RVO.
最近的一项研究表明，非 O 型血人群患视网膜静脉阻塞（RVO）的风险增加。在这项研究中，我们调查了（i）血型与 RVO 存在之间的关联，以及（ii）这种关联是否与其他 RVO 风险因素相关。
我们纳入了 485 名 RVO 患者和 295 名对照受试者，这些受试者是通过这项病例对照研究招募的。我们通过聚合酶链反应确定 ABO 基因型 rs8176719 作为 O 等位基因的标记，rs8176746 作为 B 等位基因的标记。
我们没有发现 ABO 血型与 RVO 存在之间的关联。具体来说，RVO 患者和对照受试者的 ABO 血型比例相似（p = 0.527）。在逻辑回归中，非 O 型血与 RVO 患者的odds 比增加 1.06 倍（95%CI：0.78-1.45，p = 0.693），并且这种非关联在多变量调整年龄、性别、中风和静脉血栓栓塞病史以及降脂药物联合治疗后仍然存在。
尽管非 O 型血是血栓形成和心血管疾病的已知危险因素，但它们似乎不是 RVO 发展的主要危险因素。
