Nemours Children's Hospital, Nursing Administration, 1600 Rockland Road, Wilmington, DE 19803, USA; Pediatrix Medical Group, Baltimore, MD, USA.
APRN, Solid Organ Transplant, Nemours Children's Hospital, Wilmington, DE, USA; Department, Solid Organ Transplant, Nemours Children's Health, 1600 Rockland Road, Wilmington, DE 19803, USA.
Crit Care Nurs Clin North Am. 2022 Sep;34(3):241-258. doi: 10.1016/j.cnc.2022.04.002. Epub 2022 Jul 20.
Pediatric acute liver failure is a rare diagnosis which can result in death or multiorgan system failure with a potential need for liver transplantation. The causative factors are many, but etiology, definitive pathophysiology, and directed therapies are still under investigation contributing to the difficulty in planning and providing both medical and nursing care. Clinical practice guidelines for acute liver failure are available for adult patients and through a national published position paper for pediatrics, but quality evidence is limited, especially with regard to testing and treatment recommendations, providing challenges in pediatric critical care decision making.
小儿急性肝衰竭是一种罕见的诊断，可导致死亡或多器官系统衰竭，可能需要进行肝移植。病因很多，但病因、明确的病理生理学和针对性治疗仍在研究中，这导致了医疗和护理计划的制定和提供都存在困难。急性肝衰竭的临床实践指南适用于成年患者，并且通过儿科的国家发布的立场文件，但是高质量的证据有限，特别是在测试和治疗建议方面，这给儿科危重病决策带来了挑战。
