Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.
Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
ACS Appl Mater Interfaces. 2022 Sep 14;14(36):40513-40521. doi: 10.1021/acsami.2c07281. Epub 2022 Sep 1.
Rh is a noble metal introduced in bioapplications, including diagnosis and therapy, in addition to its consolidated utilization in organic catalysis and electrocatalysis. Herein, we designed the synthesis of highly crystalline Rh nanocrystal-decorated Rh-Te nanorods (RhTeNRs) through galvanic replacement of sacrificial Te nanorod (TeNR) templates and subsequent polyol regrowth. The obtained RhTeNRs showed excellent colloidal stability and efficient heat dissipation and photocatalytic activity under various laser irradiation wavelengths. Based on the confirmed biocompatibility, RhTeNRs were introduced into and cancer phototherapies. The results confirmed the selective physical death of cancer cells in the local area through laser irradiation. While chemotherapy does not guarantee successful treatment due to side effects and resistance, phototherapy using heat and reactive oxygen species generation of RhTeNRs induces physical death.
Rh 是一种引入生物应用的贵金属，包括诊断和治疗，此外，它在有机催化和电催化中的应用也得到了巩固。在此，我们设计了通过牺牲 Te 纳米棒 (TeNR) 模板的电置换和随后的多元醇再生长来合成高度结晶的 Rh 纳米晶修饰的 Rh-Te 纳米棒 (RhTeNRs)。所获得的 RhTeNRs 在各种激光照射波长下表现出优异的胶体稳定性和有效的散热和光催化活性。基于已确认的生物相容性，将 RhTeNRs 引入 和 癌症的光疗中。结果证实，通过激光照射选择性地导致局部癌细胞的物理死亡。虽然化疗由于副作用和耐药性并不能保证治疗成功，但 RhTeNRs 产生的热和活性氧物种的光疗会导致物理死亡。
