隆胸植入物周围胶囊中的硅颗粒：建立一种新的病理学方法来评估隆胸植入物周围的颗粒数量。
Silicone particles in capsules around breast implants: Establishment of a new pathological methodology to assess the number of particles around breast implants.
作者信息
Dziubek M, Laurent R, Bonapace-Potvin M, Gaboury L, Danino M A
机构信息
Department of plastic and reconstructive surgery, University of Montreal Hospital Center (CHUM), 1000, rue Saint-Denis, Montreal, Quebec H2X 0C1, Canada.
Institute for Research in Immunology and Cancer, Université de Montréal, C.P. 6128 succursale Centre-ville, Montréal, Québec H3C 3J7, Canada.
出版信息
Ann Chir Plast Esthet. 2023 Jan;68(1):19-25. doi: 10.1016/j.anplas.2022.08.002. Epub 2022 Aug 29.
INTRODUCTION
The presence of silicone particles in breast implant capsules has been observed since the 1970s. Since then, little data has been published regarding the amount of silicone that is susceptible to migrate into the capsule. Quantifying the amount of silicone migration from the implant to the capsule could inform on the level of silicone exposure a patient with breast implants may experience in the short- or long-term. The objective of this study is to present a histological quantification methodology of the number of silicone particles present in breast implant capsules.
MATERIALS AND METHODS
A prospective study was performed on capsule samples from patients requiring revision surgery. The slides were digitalized and analyzed with a viewer software. For each sample, we (1) manually counted each silicone particle, (2) measured the average particle size, (3) measured the capsule surface area, and (4) calculated the particle number density in each capsule sample. The average of all capsule samples' particle number densities was then compared to the total volume of the capsule to estimate the total number of silicone particles found within the capsule of each breast implant.
RESULTS
Six capsules from six different patients were analyzed. Two capsules were from saline implants while four capsules were from silicone implants. All four silicone implant capsules contained between 352,928 and 9,002,235 silicone particles. The particle number density ranged from 20.5 to 683.5 particles per mm of capsule. The two saline-filled implant capsules were free of silicone particles. The average of all capsule samples' particle number densities was then compared to the total volume of the capsule to estimate the total number of silicone particles found within the capsule of each breast implant.
CONCLUSIONS
We describe a new and reproducible methodology to quantify realistically the silicone particles in the periprosthetic capsule of breast implants.
引言
自20世纪70年代以来，人们就观察到乳房植入物包膜中存在硅颗粒。从那时起，关于易迁移到包膜中的硅的量的相关数据发表得很少。量化从植入物迁移到包膜中的硅的量，可以了解乳房植入物患者在短期或长期内可能接触到的硅水平。本研究的目的是提出一种对乳房植入物包膜中存在的硅颗粒数量进行组织学量化的方法。
材料与方法
对需要翻修手术的患者的包膜样本进行了一项前瞻性研究。将载玻片数字化并用观察软件进行分析。对于每个样本，我们（1）手动计数每个硅颗粒，（2）测量平均颗粒大小，（3）测量包膜表面积，（4）计算每个包膜样本中的颗粒数密度。然后将所有包膜样本的颗粒数密度平均值与包膜总体积进行比较，以估计每个乳房植入物包膜内发现的硅颗粒总数。
结果
分析了来自6名不同患者的6个包膜。2个包膜来自盐水植入物，4个包膜来自硅酮植入物。所有4个硅酮植入物包膜中含有352,928至9,002,235个硅颗粒。颗粒数密度范围为每毫米包膜20.5至683.5个颗粒。2个盐水填充的植入物包膜中没有硅颗粒。然后将所有包膜样本的颗粒数密度平均值与包膜总体积进行比较，以估计每个乳房植入物包膜内发现的硅颗粒总数。
结论
我们描述了一种新的、可重复的方法，用于实际量化乳房植入物假体周围包膜中的硅颗粒。
Zotero 插件