Center for Regenerative Medicine, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University; Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, China.
Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
Signal Transduct Target Ther. 2022 Sep 1;7(1):305. doi: 10.1038/s41392-022-01151-3.
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao's research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer.
目前对乳酸的认识已经从其作为糖酵解的副产物的起源扩展到了其在肿瘤代谢中的作用，这是通过对瓦伯格效应的研究发现的。乳酸穿梭假说表明，乳酸作为一种桥接信号分子，在不同细胞、器官和组织之间的信号协调中发挥着重要作用。乳酸酰化是 2019 年由赵英明教授研究组首次报道的一种翻译后修饰。随后的研究证实，乳酸酰化是乳酸功能的重要组成部分，参与肿瘤增殖、神经兴奋、炎症等生物学过程。乳酸作为各种生理细胞功能所必需的物质，在能量代谢和信号转导的不同方面发挥着调节作用。因此，对乳酸进行全面的综述和总结，旨在阐明乳酸在疾病中的作用，并为未来的研究提供参考和方向。本文综述了乳酸的动态平衡及其在生理和病理过程中的作用，以及乳酸酰化在各种疾病（特别是炎症和癌症）中的作用的全面概述。
