Sasaki H, Akutagawa H, Kuwakado K, Uemura M, Emi I
Am J Hematol. 1987 Jun;25(2):215-8. doi: 10.1002/ajh.2830250212.
A 7-week-old male infant tested positive for autoimmune hemolytic anemia. Serological studies revealed a positive Coombs test and a strong antibody with relative anti-E specificity. Despite corticosteroid therapy, he frequently suffered severe hemolytic crises. During the course of the disease he had pneumonia, subcutaneous abscess, and sepsis, which were thought to be caused by his immunosuppressive state. His clinical course was chronic and refractory. Recently, high-dose intravenous IgG therapy for the treatment of chronic AIHA has been reported, but it has not been successful in the management of adult AIHA. We attempted this therapy in our patient, and successful management was obtained.
一名7周大的男婴被检测出自身免疫性溶血性贫血呈阳性。血清学研究显示库姆斯试验呈阳性，且有一种具有相对抗-E特异性的强抗体。尽管接受了皮质类固醇治疗，但他仍频繁遭受严重的溶血危机。在疾病过程中，他患了肺炎、皮下脓肿和败血症，这些被认为是由他的免疫抑制状态引起的。他的临床病程呈慢性且难治。最近，有报道称高剂量静脉注射免疫球蛋白疗法可用于治疗慢性自身免疫性溶血性贫血（AIHA），但在成人AIHA的管理中尚未取得成功。我们在我们的患者中尝试了这种疗法，并获得了成功的治疗效果。
