Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Division of Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA.
Pediatr Rheumatol Online J. 2022 Sep 1;20(1):74. doi: 10.1186/s12969-022-00730-6.
Multisystem inflammatory syndrome in children (MIS-C) is a febrile syndrome that is observed in the pediatric population following severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Vaccines have prevented or lessened the severity of the initial acute respiratory infection, while their effectiveness against severe MIS-C is just beginning to be reported.
Here we report a fully vaccinated teenage female with no known history of SARS-CoV-2 infection who presented with shock and heart failure. Her presentation was initially thought secondary to a retropharyngeal abscess but was later identified as MIS-C after confirmed nucleocapsid antibody.
Given the recent Omicron waves, the ongoing international outbreaks with evolving variants and the continued evolution of the COVID-19 pandemic, this case emphasizes the need to include MIS-C in the differential diagnosis, even in a fully vaccinated, previously healthy child.
儿童多系统炎症综合征（MIS-C）是一种在儿童人群中观察到的发热综合征，出现在严重急性呼吸综合征 2 型（SARS-CoV-2）感染之后。疫苗已预防或减轻了初始急性呼吸道感染的严重程度，而它们对严重 MIS-C 的有效性才刚刚开始报告。
这里我们报告了一例完全接种疫苗的少女，她没有已知的 SARS-CoV-2 感染史，出现了休克和心力衰竭。她的表现最初被认为是咽后脓肿引起的，但后来在确认核衣壳抗体后被确定为 MIS-C。
鉴于最近的奥密克戎浪潮、不断演变的变异株的国际爆发以及 COVID-19 大流行的持续演变，即使是在完全接种疫苗、既往健康的儿童中，也需要将 MIS-C 纳入鉴别诊断，这凸显了这一点。
