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常规筛查有慢性乙型肝炎风险的急诊入院患者(SEARCH)可以发现乙型肝炎病例,并将其与治疗相联系。

Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care.

机构信息

Department of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.

The University of New South Wales, Sydney, New South Wales, Australia.

出版信息

Liver Int. 2023 Jan;43(1):60-68. doi: 10.1111/liv.15414. Epub 2022 Sep 14.

Abstract

BACKGROUND AND AIMS

Significant barriers exist with hepatitis B (HBV) case detection and effective linkage to care (LTC). The emergency department (ED) is a unique healthcare interaction where hepatitis screening and LTC could be achieved. We examined the efficacy and utility of automated ED HBV screening for Overseas Born (OB) patients.

METHODS

A novel-automated hepatitis screening service "SEARCH" (Screening Emergency Admissions at Risk of Chronic Hepatitis) was piloted at a metropolitan hospital. A retrospective and comparative analysis of hepatitis testing during the SEARCH pilot compared to a period of routine testing was conducted.

RESULTS

During the SEARCH pilot, 4778 OB patients were tested for HBV (86% of eligible patient presentations), compared with 1.9% of eligible patients during a control period of clinician-initiated testing. SEARCH detected 108 (2.3%) hepatitis B surface antigen positive patients including 20 (19%) in whom the diagnosis was new. Among 88 patients with known HBV, 57% were receiving medical care, 33% had become lost to follow-up and 10% had never received HBV care. Overall, 30/88 (34%) patients with known HBV were receiving complete guideline-based care prior to re-engagement via SEARCH. Following SEARCH, LTC was successful achieved in 48/58 (83%) unlinked patients and 19 patients were commenced on anti-viral therapy. New diagnoses of cirrhosis and hepatocellular carcinoma were made in five and one patient(s) respectively.

CONCLUSIONS

Automated ED screening of OB patients is effective in HBV diagnosis, re-diagnosis and LTC. Prior to SEARCH, the majority of patients were not receiving guideline-based care.

摘要

背景和目的

乙型肝炎(HBV)病例检测和有效衔接护理(LTC)存在重大障碍。急诊科(ED)是一个独特的医疗保健互动场所,可在此进行肝炎筛查和 LTC。我们研究了自动 ED HBV 筛查对海外出生(OB)患者的疗效和实用性。

方法

在一家大都市医院试点了一种新型自动化肝炎筛查服务“SEARCH”(筛查慢性肝炎风险的急诊入院)。对 SEARCH 试点期间的肝炎检测与常规检测期间进行了回顾性和对比分析。

结果

在 SEARCH 试点期间,4778 名 OB 患者接受了 HBV 检测(占合格患者就诊的 86%),而在常规检测期间,只有 1.9%的合格患者接受了检测。SEARCH 发现了 108 例乙型肝炎表面抗原阳性患者,其中 20 例(19%)为新诊断。在 88 例已知 HBV 的患者中,57%正在接受医疗护理,33%已失访,10%从未接受过 HBV 护理。总体而言,在通过 SEARCH 重新联系之前,30/88(34%)例已知 HBV 的患者接受了基于指南的完整护理。通过 SEARCH 后,成功实现了 48/58(83%)例未链接患者的 LTC,并且有 19 例患者开始接受抗病毒治疗。分别在 5 例和 1 例患者中发现了新的肝硬化和肝细胞癌诊断。

结论

对 OB 患者进行自动 ED 筛查可有效诊断、重新诊断和治疗 HBV 并进行 LTC。在 SEARCH 之前,大多数患者未接受基于指南的护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dab/10087472/a7cb2ccb3b83/LIV-43-60-g002.jpg

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