Zhang Qiang, Knies Andrea K, Pach Jolanta, Kimbrough Tara, Martinez Aida, Juthani Prerak, Tu Stephanie, Monin Joan K, Vranceanu Ana-Maria, Hwang David Y
Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT.
Department of Emergency Medicine, Yale School of Medicine, Yale University, New Haven, CT.
Crit Care Explor. 2022 Aug 29;4(9):e0753. doi: 10.1097/CCE.0000000000000753. eCollection 2022 Sep.
To determine the degree to which an ICU patient's family member having an "anxious" psychologic attachment orientation is a risk factor for developing long-term posttraumatic stress disorder (PTSD) symptoms following patient ICU discharge or death.
Prospective cohort study.
Single academic neuroscience ICU from November 2017 to September 2020.
Consecutively enrolled sample of family members, one for each ICU patient with a minimum length of stay of 24 hours.
None.
Near time of ICU discharge or patient death, we determined each participant's psychologic attachment orientation as anxious versus nonanxious via a brief standard survey tool, the Relationship Questionnaire, and measured other participant and patient characteristics as potential covariates. Six months after discharge or death, each participant completed the Impact of Events Scale-Revised (IES-R) to measure PTSD symptoms, with a score of greater than 24 indicative of clinically significant symptoms. Among 162 total participants, 10 of 27 participants (37.0%) with an anxious attachment orientation reported 6-month PTSD symptoms, compared with 24 of 135 nonanxious participants (17.8%) (relative risk, 2.08; 95% CI, 1.13-3.84; = 0.02; risk difference 19.2%). In a subsequent univariate analysis of participant and patient covariates, anxious attachment orientation, participant Hispanic ethnicity, prior experience as a care partner of a patient with a disability, and participation in 3 or more formal ICU family meetings were all associated with 6-month PTSD symptoms. In a multiple logistic regression, anxious attachment remained an independent predictor of 6-month PTSD symptoms (odds ratio [OR], 3.64; 95% CI, 1.35-9.77; = 0.01), as did Hispanic ethnicity (OR, 4.72; 95% CI, 1.34-16.6; = 0.01) and participation in three or more ICU family meetings (odds ratio, 2.97; 95% CI, 1.14-7.68; = 0.02).
An anxious psychologic attachment orientation is associated with double the risk of long-term PTSD symptoms among family members of ICU patients. Future interventions designed to decrease risk of adverse psychologic outcomes among ICU families could be initially tested for efficacy amongst those who fall into this high-risk category.
确定重症监护病房(ICU)患者的家庭成员具有“焦虑”心理依恋倾向在患者从ICU出院或死亡后出现长期创伤后应激障碍(PTSD)症状的风险因素程度。
前瞻性队列研究。
2017年11月至2020年9月的一家学术性神经科学ICU。
连续纳入的家庭成员样本,每位入住ICU至少24小时的患者对应一名家庭成员。
无。
在ICU出院或患者死亡临近时,我们通过一种简短的标准调查工具——关系问卷,确定每位参与者的心理依恋倾向是焦虑型还是非焦虑型,并测量其他参与者和患者特征作为潜在协变量。出院或死亡6个月后,每位参与者完成事件影响量表修订版(IES-R)以测量PTSD症状,得分大于24表明存在具有临床意义的症状。在总共162名参与者中,27名具有焦虑依恋倾向的参与者中有十名(37.0%)报告有6个月PTSD症状,相比之下,135名非焦虑参与者中有24名(17.8%)(相对风险为2.08;95%置信区间为1.13 - 3.84;P = 0.02;风险差异为19.2%)。在随后对参与者和患者协变量的单变量分析中,焦虑依恋倾向、参与者西班牙裔种族、之前作为残疾患者护理伙伴的经历以及参加3次或更多次正式的ICU家属会议均与6个月PTSD症状相关。在多元逻辑回归中,焦虑依恋仍然是6个月PTSD症状的独立预测因素(比值比[OR]为3.64;95%置信区间为1.35 - 9.77;P = 0.01),西班牙裔种族(OR为4.72;95%置信区间为1.34 - 16.6;P = 0.01)以及参加3次或更多次ICU家属会议(比值比为2.97;95%置信区间为1.14 - 7.68;P = 0.02)也是如此。
焦虑的心理依恋倾向与ICU患者家庭成员长期出现PTSD症状的风险增加一倍有关。未来旨在降低ICU患者家属不良心理结果风险的干预措施可首先在这类高风险人群中测试其疗效。