Department of Hepatopancreatobiliary Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 317000, China.
Division of Liver Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Can J Gastroenterol Hepatol. 2022 Aug 23;2022:7750140. doi: 10.1155/2022/7750140. eCollection 2022.
A retrospective cohort study was conducted to collect 465 patients with hepatitis B-related hepatocellular carcinoma who had undergone radical hepatectomy from January 1, 2012, to August 31, 2018, at the First Affiliated Hospital of the University of Science and Technology of China. The clinical, pathological, and follow-up information was collected to compare the basic characteristics of death and nondeath after radical resection. Kaplan-Meier curves were used for survival analysis and male and female subgroup analysis. The multivariate Cox proportional-hazards regression model was used to analyze independent risk factors related to postoperative death. Of the 465 patients with radical resection of hepatitis B-related hepatocellular carcinoma, 132 died, and 1-, 3-, and 5-year cumulative survival rates after operation were 92.1%, 78%, and 64%, respectively. In the male and female subgroup, 115 and 17 patients died, respectively. The 1-, 3-, and 5-year cumulative survival rates were 92.6%, 77.0%, and 62.6%, respectively, in men, and 89.6%, 78.8%, and 70.2%, respectively, in women. Multivariate Cox proportional-hazards regression analysis showed that microvascular invasion (MVI), Edmondson III/IV, BCLC stage B, and total bilirubin (TB) > 20.5 mol/L were independent risk factors in patients with hepatitis B-related hepatocellular carcinoma after radical hepatectomy.
一项回顾性队列研究收集了 2012 年 1 月 1 日至 2018 年 8 月 31 日期间在科技大学第一附属医院接受根治性肝切除术的 465 例乙型肝炎相关肝细胞癌患者的临床、病理和随访信息，以比较根治性切除术后死亡和非死亡患者的基本特征。采用 Kaplan-Meier 曲线进行生存分析和男女亚组分析。采用多变量 Cox 比例风险回归模型分析与术后死亡相关的独立危险因素。在接受根治性乙型肝炎相关肝细胞癌切除术的 465 例患者中，有 132 例死亡，术后 1、3 和 5 年累积生存率分别为 92.1%、78%和 64%。在男性和女性亚组中，分别有 115 例和 17 例死亡，男性患者的 1、3 和 5 年累积生存率分别为 92.6%、77.0%和 62.6%，女性患者分别为 89.6%、78.8%和 70.2%。多变量 Cox 比例风险回归分析显示，微血管侵犯（MVI）、Edmondson III/IV 级、BCLC 分期 B 和总胆红素（TB）>20.5μmol/L 是乙型肝炎相关肝细胞癌根治性肝切除术后的独立危险因素。
