Matsuoka L Y, Goldman J, Wortsman J, Kleinsmith D, Kupchella C E
Am J Med. 1987 Jun;82(6):1253-6. doi: 10.1016/0002-9343(87)90235-x.
Acanthosis nigricans is a skin disorder associated with endocrine abnormalities, autoimmune disease, and systemic malignancies. Insulin resistance is a common accompaniment of the nonmalignant varieties of acanthosis nigricans. A 44-year-old man is described with a functioning metastatic pheochromocytoma, acanthosis nigricans, and insulin-resistant diabetes mellitus. Studies of insulin action showed a low titer of anti-insulin antibodies and a very high titer of antibodies against the insulin receptor. This case documents for the first time insulin resistance due to anti-insulin receptor antibodies in a paraneoplastic variety of acanthosis nigricans.
黑棘皮病是一种与内分泌异常、自身免疫性疾病和全身性恶性肿瘤相关的皮肤疾病。胰岛素抵抗是黑棘皮病非恶性类型的常见伴随症状。本文描述了一名44岁男性，患有功能性转移性嗜铬细胞瘤、黑棘皮病和胰岛素抵抗型糖尿病。胰岛素作用研究显示抗胰岛素抗体滴度低，而抗胰岛素受体抗体滴度非常高。该病例首次证明了副肿瘤性黑棘皮病中由抗胰岛素受体抗体导致的胰岛素抵抗。
