Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma.

Glioblastoma (GBM) is a high-grade, aggressive brain tumor with dismal median survival time of 15 months. Chromosome 6q (Ch6q) is a hotspot of genomic alterations, which is commonly deleted or hyper-methylated in GBM. Two neighboring genes in this region, and have been appointed as tumor suppressors in GBM. While a genetically modified mouse model (GEMM) of GBM has been successfully generated with deletion in the central nervous system (CNS), genetic evidence supporting the tumor suppressor function of has not been established. In the present study, we generated a mouse model with -null allele and conditional and deletions in the neural stem cells (NSCs) and compared the tumorigenicity of this model to our previous GBM model with deletion within the same system. We find that but not is the potent tumor suppressor in the frequently altered Ch6q region in GBM.