Alayed Doaa M, Pharaon Majed M
Department of Pathology and Laboratory Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
Department of Pathology and Laboratory Medicine, Ministry of National Guard, Riyadh, Saudi Arabia.
Avicenna J Med. 2022 Jun 21;12(2):87-92. doi: 10.1055/s-0042-1749611. eCollection 2022 Apr.
Low-grade fibromyxoid sarcoma (LGFMS), also known as Evan's tumor, is a fibroblastic tumor with a deceptively bland morphology but a high metastasizing potential and late recurrence. It presents clinically as a slowly growing mass in the deep soft tissue of extremities and trunk. Morphologically, it shows a biphasic pattern with alternating fibrous and myxoid areas, whorling growth pattern, hypocellularity, and bland fibroblasts with curvilinear or arcuate vessels in between. Collagen rosettes with central hyalinization is a helpful feature but not specific. MUC-4 is the most sensitive immunostain in LGFMS. The majority of cases harbor a gene fusion in - Herein, we present a 23-year-old female patient with a slow growing painless mass in the left parotid gland, which was later diagnosed as LGFMS. Involvement of the head and neck region by LGFMS is uncommonly encountered. To date, only two cases within the parotid gland have been described.
低度纤维黏液样肉瘤（LGFMS），也称为埃文斯瘤，是一种成纤维细胞性肿瘤，形态看似温和，但具有高转移潜能和晚期复发的特点。临床上，它表现为四肢和躯干深部软组织中缓慢生长的肿块。形态学上，它呈现双相模式，有交替的纤维和黏液样区域、漩涡状生长模式、细胞稀少，以及其间有曲线或弧形血管的温和的成纤维细胞。中央玻璃样变的胶原玫瑰花结是一个有用的特征，但不具有特异性。MUC-4是LGFMS中最敏感的免疫染色。大多数病例存在基因融合——在此，我们报告一名23岁女性患者，其左侧腮腺有一个缓慢生长的无痛性肿块，后来被诊断为LGFMS。LGFMS累及头颈部区域的情况并不常见。迄今为止，仅描述过两例发生于腮腺内的病例。
