Gupta Vaibhav, Maurya Malti Kumari, Agarwal Preeti, Kumar Madhu, Sagar Mala, Raghuvanshi Shivanjali, Gupta Sameer
Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2022 May-Aug;13(2):208-215. doi: 10.4103/njms.njms_402_21. Epub 2022 Jul 15.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a key aldehyde dehydrogenase (ALDH) isozyme, related to the cancer stem cells which are responsible for initiating tumor growth, progression, and recurrence. High expression of ALDH1A1 has been reported in several tumor types in humans and its expression is associated with poor prognosis. The aim of this study was to assess the expression of the ALDH1A1 in oral squamous cell carcinoma (SCC) and its correlation with various clinicopathological parameters.
ALDH1A1 expression was analyzed by using immunohistochemistry on paraffin blocks of 112 cases of primary oral SCC and their corresponding 68 lymph nodes with metastatic deposits. ALDH1A1 expression was also correlated with various clinicopathological parameters. Statistical analysis was done with statistical analysis software, the Statistical Package for the Social Sciences version 21.0.
High ALDH1A1 expression was observed in 31.2% of cases of primary oral SCC as compared to 73.5% in lymph node metastasis. A statistically significant difference ( = 0.04) was observed in high TNM stages (68.6%) of the tumor as compared to low TNM stages (31.4%). However, histopathological grades of tumor showed nonsignificant correlation with ALDH1A1 expression ( = 0.093). 40.2% of patients were expired at the end of the study, and the rate of mortality was significantly higher ( = 0.01) in patients with high ALDH1A1 expression as compared to low expression (60.0% vs. 31.2%).
High ALDH1A1 expression was associated with higher TNM tumor stage and high nodal stage. It was also associated with high mortality rate which validates it as a marker of invasiveness and poor prognosis in oral SCC.
醛脱氢酶1A1（ALDH1A1）是一种关键的醛脱氢酶（ALDH）同工酶，与负责启动肿瘤生长、进展和复发的癌症干细胞相关。据报道，ALDH1A1在人类多种肿瘤类型中高表达，其表达与预后不良相关。本研究旨在评估ALDH1A1在口腔鳞状细胞癌（SCC）中的表达及其与各种临床病理参数的相关性。
采用免疫组织化学方法分析112例原发性口腔SCC石蜡块及其相应的68个有转移灶的淋巴结中ALDH1A1的表达。ALDH1A1表达也与各种临床病理参数相关。使用统计分析软件社会科学统计软件包21.0进行统计分析。
原发性口腔SCC病例中31.2%观察到ALDH1A1高表达，而淋巴结转移病例中为73.5%。与低TNM分期（31.4%）相比，肿瘤高TNM分期（68.6%）存在统计学显著差异（P = 0.04）。然而，肿瘤的组织病理学分级与ALDH1A1表达无显著相关性（P = 0.093）。40.2%的患者在研究结束时死亡，ALDH1A1高表达患者的死亡率显著高于低表达患者（60.0%对31.2%，P = 0.01）。
ALDH1A1高表达与较高的TNM肿瘤分期和高淋巴结分期相关。它还与高死亡率相关，这证实了它作为口腔SCC侵袭性和预后不良标志物的地位。
