中国南方人群中rs6897932与多发性硬化症风险的关联
The Association of rs6897932 with Risk of Multiple Sclerosis in Southern Chinese.
作者信息
Zhao Zongbo, Xue Jianzhong, Zhuo Ziliang, Zhong Wei, Liu Hui
机构信息
Department of Neurology and Institute of Neurology, The Affiliated Changshu Hospital of Xuzhou Medical University, Suchow, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2022 Aug 26;18:1855-1859. doi: 10.2147/NDT.S376066. eCollection 2022.
OBJECTIVE
To investigate the association between rs6897932 and multiple sclerosis (MS) in southern Chinese people.
METHODS
In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.
RESULTS
With genetic models, we can observe that the additive model, the dominant model, and the recessive model of rs6897932 were significantly associated with MS [additive model: =0.032; dominant model (adjusted): <0.001, OR=3.61 (95% CI 2.25-5.83); recessive model (adjusted): <0.001, OR=6.80 (95% CI 3.49-13.89)].
CONCLUSION
Our results suggest that rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.
目的
探讨中国南方人群中rs6897932与多发性硬化症（MS）之间的关联。
方法
根据修订的麦克唐纳标准，共招募了147例MS患者和530名健康对照。采用TaqMan方法进行基因分型。
结果
在遗传模型中，我们可以观察到rs6897932的加性模型、显性模型和隐性模型均与MS显著相关[加性模型：=0.032；显性模型（校正后）：<0.001，OR=3.61（95%CI 2.25 - 5.83）；隐性模型（校正后）：<0.001，OR=6.80（95%CI 3.49 - 13.89）]。
结论
我们的结果表明，rs6897932与中国南方人群的MS相关。有必要开展更多更大规模的MS研究以探索MS的遗传危险因素。
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