College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
Mol Biol Rep. 2011 Nov;38(8):5079-84. doi: 10.1007/s11033-010-0654-5. Epub 2010 Dec 16.
Previously published analyses of the association between the interleukin 7 receptor (IL7R) T244I polymorphism (rs6897932) and multiple sclerosis (MS) have yielded conflicting results. We performed a meta-analysis to assess whether the combined data showed this association, and to investigate its effect size. We analyzed 10 studies identified from PubMed (12,185 MS patients and 15,855 controls) and calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for the C-allele, the C/C genotype (recessive effect) and the C/C + C/T (dominant effect) genotype. Heterogeneity within and between studies was observed: allele C: Q = 30.86, P = 0.002; genotype C/C: Q = 30.28, P = 0.003. Using a random-effects model, the C-allele and the C/C genotype were associated with MS (OR = 1.11, 95% CI = 1.04-1.19, P = 0.001 for the C-allele; OR = 1.15, 95% CI = 1.06-1.24, P = 0.0009 for the C/C genotype). The C/C + C/T genotype was also associated with MS using a fixed-effects model (OR = 1.15, 95% CI = 1.05-1.26, P = 0.003). There was no significant publication bias among the selected studies according to the funnel plot. We also performed the analysis on a European subgroup. This revealed an association between IL7R T244I and MS (P < 0.00001 for the C-allele and the C/C genotype; P = 0.0004 for the C/C + C/T genotype), no heterogeneity was observed (allele C: P = 0.07; genotype C/C: P = 0.10). In conclusion, the meta-analysis demonstrated that the IL7R T244I polymorphism was associated with susceptibility to MS.
先前发表的关于白细胞介素 7 受体 (IL7R) T244I 多态性 (rs6897932) 与多发性硬化症 (MS) 之间关联的分析结果存在矛盾。我们进行了荟萃分析，以评估合并数据是否显示出这种关联，并探讨其效应大小。我们分析了从 PubMed 中确定的 10 项研究（12185 例 MS 患者和 15855 名对照），并计算了 C 等位基因、C/C 基因型（隐性效应）和 C/C+C/T（显性效应）基因型的比值比 (OR) 和 95%置信区间 (CI)。研究内和研究间存在异质性：等位基因 C：Q = 30.86，P = 0.002；基因型 C/C：Q = 30.28，P = 0.003。使用随机效应模型，C 等位基因和 C/C 基因型与 MS 相关（OR = 1.11，95%CI = 1.04-1.19，P = 0.001 用于 C 等位基因；OR = 1.15，95%CI = 1.06-1.24，P = 0.0009 用于 C/C 基因型）。使用固定效应模型，C/C+C/T 基因型也与 MS 相关（OR = 1.15，95%CI = 1.05-1.26，P = 0.003）。根据漏斗图，所选研究中没有明显的发表偏倚。我们还在欧洲亚组中进行了分析。这表明 IL7R T244I 与 MS 之间存在关联（C 等位基因和 C/C 基因型 P <0.00001；C/C+C/T 基因型 P = 0.0004），没有观察到异质性（等位基因 C：P = 0.07；基因型 C/C：P = 0.10）。总之，荟萃分析表明白细胞介素 7 受体 T244I 多态性与多发性硬化症的易感性相关。
