Ann Ital Chir. 2022;92:313-318.
Small stone fragments (NSRF) may be observed after mini-invasive lithotripsy. A 3-components herbal extract drug was tested in young patients presenting NSRF to assess efficacy, safety and tolerability.
Patients aged 6-18 years, treated by endo-urological procedures in 5-year period, were randomly divided in 2 groups. Group A received a 3-components phytotherapic composed of Herniaria hirsuta and Peumus boldus plus water oral intake for 12 days/month in 3 months. Group B had no adjuvant phytotherapy. Group A and B were divided in 2 subgroups, according to persistence of NSRF. Patients were evaluated after the endo-urological procedure (Time 0), at 3-months therapy (Time 1) and after 3-months follow-up (Time 2). Persistence or development of new micro-lithiasis, adverse effects and urological check were registered.
Thirty-four patients were enrolled (Group A=15, Group B=19). Two patients were excluded. In Group A, 6 patients were stone free at Time 0 and had no recurrence, while 7 patients (53.8%) had NSRF at Time 0, reduced to 3 (23.0%) and to 2 (15.4%) at Time 1 and 2 respectively. In Group B, 11 patients (57.9%) presented NSRF at Time 0, reduced to 8 (42.1%) and 7 (36.8%) at Time 1 and 2. The difference was significant (Time 1 p=0.006, Time 2 p=0.009). No adverse effects were reported.
The drug was effective in preventing new stones development and reducing significantly stone fragments persisting after endo-urological lithotripsy in children, with optimal tolerability and no adverse effects.
Arbutin, Boldine, Phytotherapy, Pediatrics, Umbelliferone, Urinary tract stones.
微创碎石术后可能会观察到小结石碎片（NSRF）。对一种由三种草药提取物组成的药物在患有 NSRF 的年轻患者中进行了测试，以评估其疗效、安全性和耐受性。
6-18 岁的患者，在 5 年内接受内镜泌尿外科治疗，随机分为两组。A 组接受一种由 Herniera hirsuta 和 Peumus boldus 组成的三种草药植物疗法，外加口服水，持续 12 天/月，共 3 个月。B 组无辅助植物疗法。A 组和 B 组根据 NSRF 的持续情况分为两个亚组。在内镜泌尿外科手术后（时间 0）、治疗 3 个月时（时间 1）和 3 个月随访后（时间 2）对患者进行评估。记录 NSRF 的持续或新的微结石形成、不良反应和泌尿科检查情况。
共纳入 34 名患者（A 组 15 名，B 组 19 名）。两名患者被排除在外。在 A 组中，6 名患者在时间 0 时无结石，且无复发，而 7 名患者（53.8%）在时间 0 时存在 NSRF，在时间 1 和时间 2 时分别减少到 3 名（23.0%）和 2 名（15.4%）。在 B 组中，11 名患者（57.9%）在时间 0 时存在 NSRF，在时间 1 和时间 2 时分别减少到 8 名（42.1%）和 7 名（36.8%）。差异有统计学意义（时间 1，p=0.006；时间 2，p=0.009）。未报告不良反应。
该药物可有效预防新结石的形成，并显著减少儿童内镜碎石术后 NSRF 的持续存在，具有最佳的耐受性且无不良反应。
熊果苷、博宁、植物疗法、儿科、伞形酮、尿路结石。
