Key Laboratory of Environment Correlative Dietology (Ministry of Education), College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
Food Funct. 2022 Oct 3;13(19):9893-9903. doi: 10.1039/d2fo01602h.
Ginger is a traditional medicinal and edible plant with multiple health-promoting properties. Nevertheless, the effects and potential mechanism of ginger on antiaging remain unknown. The aim of this study was to comprehend the antiaging effects and potential mechanism of ginger in (). The current findings showed that the lifespan of was prolonged by 23.16% with the supplementation of 60 μg mL ginger extract (GE), and the extension of lifespan was mainly attributed to the major bioactive compounds in GE, 6-, 8-, 10-gingerol and 6-, 8-, 10-shogaol. Subsequently, GE promoted healthy aging by improving nematode movement and attenuating lipofuscin accumulation, and enhanced stress tolerance by up-regulating the expression of stress-related genes and activating DAF-16 and SKN-1. Moreover, lifespan assays of relative mutants revealed that GE mediated extension of lifespan the insulin/IGF-1 signaling (IIS) pathway. In summary, GE endowed nematodes () with longevity and stress resistance in an IIS pathway dependent manner.
生姜是一种具有多种促进健康特性的传统药用和食用植物。然而，生姜在抗衰老方面的作用和潜在机制尚不清楚。本研究旨在了解生姜在（）中的抗衰老作用和潜在机制。目前的研究结果表明，补充 60μg/mL 生姜提取物（GE）可使线虫的寿命延长 23.16%，寿命的延长主要归因于 GE 中的主要生物活性化合物，6-、8-、10-姜酚和 6-、8-、10-姜辣素。随后，GE 通过改善线虫运动和减弱脂褐素积累来促进健康衰老，并通过上调与应激相关的基因表达和激活 DAF-16 和 SKN-1 来增强应激耐受性。此外，相对突变体的寿命测定表明，GE 通过胰岛素/IGF-1 信号通路（IIS）介导线虫寿命的延长。总之，GE 使线虫（）具有长寿和应激抗性，这种作用依赖于 IIS 通路。
