烹饪香草艾叶促进寿命和应激耐受性的分子机制。

Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance.

作者信息

Wang Jinsong, Zhu Deyan, Cui Hailin, Xu Yan, Shang Shuyou, Miao Yuanxin, Xu Zhimin, Li Rong

机构信息

Institute of Agricultural Biotechnology, Jingchu University of Technology, Jingmen, China.

Characteristic food function mining and comprehensive utilization research center, Jingchu University of Technology, Jingmen, China.

出版信息

NPJ Sci Food. 2024 Dec 24;8(1):111. doi: 10.1038/s41538-024-00358-8.

Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The positive results suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body.

艾叶（Artemisia argyi Lévl. et Vant.）叶因其主要生物活性黄酮类化合物而具有多种促进健康的功能。在本研究中，以秀丽隐杆线虫（Caenorhabditis elegans，简称C. elegans）为模型，鉴定了艾叶提取物（AALE）的抗衰老作用及其机制。结果表明，AALE可延长秀丽隐杆线虫的寿命并增强其抗逆性。研究发现，AALE通过调节胰岛素/胰岛素样生长因子-1信号（IIS）通路来提高氧化应激相关蛋白的表达，进而激活转录因子DAF-16/FOXO。RNA序列分析结果表明，用AALE处理的线虫中基因的变化与抗氧化应激、细胞成熟、免疫反应及应激反应有关。这些积极结果表明，艾叶对改善人体健康衰老以及预防与衰老相关的疾病可能具有显著益处。