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产前表现的肾上腺皮质肿瘤。

Prenatal presentation of an adrenocortical tumor.

机构信息

Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA.

UF Health Pediatric Subspecialty Clinic, Pensacola, Florida, USA.

出版信息

Cancer Rep (Hoboken). 2022 Oct;5(10):e1670. doi: 10.1002/cnr2.1670. Epub 2022 Sep 2.

DOI:10.1002/cnr2.1670
PMID:36052764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9575483/
Abstract

BACKGROUND

Prenatally identified suprarenal masses are most often found to be adrenal hemorrhage. The most common tumor in this situation is neuroblastoma.

CASE PRESENTATION

We report the case of a rare adrenocortical tumor found prenatally on ultrasound. While most patients with adrenocortical tumors present with virilizing symptoms, our patient did not have evidence of virilization and was presumed to have neuroblastoma.

CONCLUSION

Following a period of observation, our patient underwent surgical resection due to tumor growth revealing the unexpected diagnosis.

摘要

背景

产前发现的肾上腺肿块大多为肾上腺出血。在这种情况下,最常见的肿瘤是神经母细胞瘤。

病例介绍

我们报告了一例罕见的产前超声发现的肾上腺皮质肿瘤病例。大多数肾上腺皮质肿瘤患者表现为男性化症状,而我们的患者没有男性化的证据,因此被认为患有神经母细胞瘤。

结论

经过一段时间的观察,由于肿瘤生长,我们的患者接受了手术切除,结果显示出意外的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a835/9575483/3ab9a5800329/CNR2-5-e1670-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a835/9575483/3ab9a5800329/CNR2-5-e1670-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a835/9575483/3ab9a5800329/CNR2-5-e1670-g001.jpg

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本文引用的文献

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Adrenocortical Tumors in Children With Constitutive Chromosome 11p15 Paternal Uniparental Disomy: Implications for Diagnosis and Treatment.儿童先天性 11p15 染色体单亲二体性肾上腺皮质肿瘤:对诊断和治疗的影响。
Front Endocrinol (Lausanne). 2021 Nov 5;12:756523. doi: 10.3389/fendo.2021.756523. eCollection 2021.
2
Prenatal Imaging Diagnosis of Suprarenal Lesions.产前影像学诊断肾上腺病变。
Fetal Diagn Ther. 2021;48(3):235-242. doi: 10.1159/000512689. Epub 2021 Mar 17.
3
Clinical Impact of Pathological Features Including the Ki-67 Labeling Index on Diagnosis and Prognosis of Adult and Pediatric Adrenocortical Tumors.
Ki-67 标记指数在内的病理特征对成人和儿童肾上腺皮质肿瘤诊断和预后的临床影响。
Endocr Pathol. 2021 Jun;32(2):288-300. doi: 10.1007/s12022-020-09654-x. Epub 2021 Jan 14.
4
Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience.儿童肾上腺皮质肿瘤的临床、遗传和预后特征:一项为期10年的单中心经验
Front Oncol. 2020 Oct 15;10:554388. doi: 10.3389/fonc.2020.554388. eCollection 2020.
5
Pathological prognostication of paediatric adrenocortical tumours: Is a gold standard emerging?儿科肾上腺皮质肿瘤的病理预后:是否出现金标准?
Pediatr Blood Cancer. 2019 Apr;66(4):e27567. doi: 10.1002/pbc.27567. Epub 2018 Dec 11.
6
Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review.重新审视病理分级在小儿肾上腺皮质肿瘤中的作用:一项全国性队列研究的结果,该研究进行了病理复查。
Mod Pathol. 2019 Apr;32(4):546-559. doi: 10.1038/s41379-018-0174-8. Epub 2018 Nov 6.
7
Li-Fraumeni Syndrome.李-弗劳梅尼综合征
J Pediatr Genet. 2016 Jun;5(2):84-8. doi: 10.1055/s-0036-1579759. Epub 2016 Apr 13.
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Pediatr Radiol. 2016 Feb;46(2):246-54. doi: 10.1007/s00247-015-3470-1. Epub 2015 Nov 20.
9
Neonatal suprarenal mass: differential diagnosis and treatment.新生儿肾上腺肿块:鉴别诊断与治疗。
J Cancer Res Clin Oncol. 2013 Feb;139(2):281-6. doi: 10.1007/s00432-012-1316-x. Epub 2012 Oct 11.
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A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children's Oncology Group study.一项针对小婴儿神经母细胞瘤期待观察作为一线治疗的前瞻性研究:一项儿童肿瘤协作组研究。
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