Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
Laboratory of Bariatric and Nutritional Neuroscience, Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Obesity (Silver Spring). 2022 Oct;30(10):2005-2013. doi: 10.1002/oby.23529. Epub 2022 Sep 2.
Reduced dorsolateral prefrontal cortex (dlPFC) activity and inhibitory control may contribute to obesity. The study objective was to assess effects of repeated transcranial direct current stimulation (tDCS) on food Go/No-Go (GNG), food Stroop performance, and snack food intake.
Twenty-nine individuals with obesity (12 male; mean [SD], age 42 [11] years; BMI 39 [8]) participated in a combined inpatient/outpatient randomized parallel-design trial and received 15 sessions of anodal or sham tDCS to the left dlPFC. Food-related inhibitory control (GNG), attentional bias (Stroop), and snack food intake were assessed at baseline, completion of inpatient sessions (day 7), and follow-up (day 31).
GNG performance improved in the anodal group by day 31, compared with sham (p = 0.01), but Stroop scores did not differ by intervention. Greater snack food intake was associated with lower GNG scores (p = 0.01), driven by the sham group (p < 0.001) and higher food and palatable bias scores on the Stroop (all p = 0.02) across both groups. Changes on tasks were not associated with changes in intake.
Anodal tDCS to the left dlPFC improved performance on a food-related inhibitory control task, providing evidence of potential for therapeutic benefit of neuromodulation in areas controlling executive function. Results showed that tDCS to the dlPFC reduced snack food intake and hunger; however, underlying neurocognitive mechanisms remain uncertain.
背外侧前额叶皮质（dlPFC）活动减少和抑制控制能力下降可能与肥胖有关。本研究旨在评估重复经颅直流电刺激（tDCS）对食物 Go/No-Go（GNG）、食物 Stroop 任务和零食摄入量的影响。
29 名肥胖患者（男性 12 名，平均[标准差]年龄 42[11]岁，BMI 39[8]）参与了一项联合住院/门诊随机平行设计试验，接受了 15 次左侧 dlPFC 阳极或假 tDCS 治疗。在基线、住院疗程结束时（第 7 天）和随访时（第 31 天）评估与食物相关的抑制控制（GNG）、注意力偏向（Stroop）和零食摄入量。
与假刺激组相比，阳极组在第 31 天的 GNG 表现得到改善（p=0.01），但 Stroop 评分无差异。更大的零食摄入量与更低的 GNG 评分相关（p=0.01），这主要是由假刺激组（p<0.001）和 Stroop 中更高的食物和美味偏好评分驱动（所有 p=0.02）。两组任务的变化与摄入量的变化无关。
左侧 dlPFC 的阳极 tDCS 改善了与食物相关的抑制控制任务的表现，为神经调节在控制执行功能的区域具有治疗益处提供了证据。结果表明，dlPFC 的 tDCS 减少了零食摄入量和饥饿感；然而，潜在的神经认知机制仍不确定。
