用于图像引导下保留神经手术的神经特异性荧光团的先导优化
Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures.
作者信息
Barth Connor W, Wang Lei G, Montano Antonio, Antaris Alexander L, Klaassen Alwin, Sorger Jonathan, Kerr Darcy A, Henderson Eric R, Alani Adam W G, Gibbs Summer L
机构信息
Inherent Targeting, Portland, OR, 97201.
Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
出版信息
Opt Mol Probes Imaging Drug Deliv. 2021 Apr;2021. doi: 10.1364/OMP.2021.OW3E.3.
Abstract
Nerve damage is a major complication of surgery, causing pain and loss of function. We have identified novel near-infrared nerve-specific fluorophores that provide excellent nerve contrast with the ability to identify buried nerve tissue.
摘要
神经损伤是手术的主要并发症，会导致疼痛和功能丧失。我们已经鉴定出新型近红外神经特异性荧光团，其能提供出色的神经对比度，并具备识别深部神经组织的能力。
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