Department of Biomedical Engineering, Center for Spatial Systems Biomedicine, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Quant Imaging Med Surg. 2012 Sep;2(3):177-87. doi: 10.3978/j.issn.2223-4292.2012.09.04.
Near infrared (NIR) image-guided surgery holds great promise for improved surgical outcomes. A number of NIR image-guided surgical systems are currently in preclinical and clinical development with a few approved for limited clinical use. In order to wield the full power of NIR image-guided surgery, clinically available tissue and disease specific NIR fluorophores with high signal to background ratio are necessary. In the current review, the status of NIR image-guided surgery is discussed along with the desired chemical and biological properties of NIR fluorophores. Lastly, tissue and disease targeting strategies for NIR fluorophores are reviewed.
近红外(NIR)图像引导手术有望改善手术效果。目前有许多 NIR 图像引导手术系统处于临床前和临床开发阶段,少数系统已获准有限临床使用。为了充分发挥 NIR 图像引导手术的威力,需要具有高信噪比的临床可用的组织和疾病特异性 NIR 荧光团。在本综述中,讨论了 NIR 图像引导手术的现状以及 NIR 荧光团的理想化学和生物学特性。最后,回顾了 NIR 荧光团的组织和疾病靶向策略。