Department of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
J Cosmet Dermatol. 2022 Nov;21(11):6336-6342. doi: 10.1111/jocd.15282. Epub 2022 Sep 2.
BACKGROUND/OBJECTIVES: The diagnosis of psoriasis is usually established on clinical grounds but there is lacking of such diagnostic tools to stratify its severity. Psoriasis is a chronic inflammatory disease of skin, nails, and joints. Dermoscopy represent a novel diagnostic tool to diagnose and assess psoriasis severity. The main purpose of this study is to assess the value of dermoscopy associated with serum level of high-mobility group box-1 level (HMGB-1) in the diagnosis and stratification of psoriasis severity.
This study included 60 Egyptians subdivided into two equal groups, psoriatic patients, and controls. All patients were subjected first to dermoscopic examination, and then we evaluated the serum levels of HMGB-1 among all studied groups.
The level of HMGB-1 increased in psoriatic patients than controls. There was significant difference between patients and controls in the serum levels of HMGB -1. There were also a positive significant correlation between HMGB-1 and different stages of disease severity. There were also significant correlations between HMGB-1 and specific dermoscopic findings like vascular pattern and vascular number, erythema grades as well as types of scales (Fine, coarse) and (Fine, thick).
Dermoscopy and HMGB-1 can be considered as a combined novel diagnostic tool for psoriasis severity.
背景/目的：银屑病的诊断通常基于临床依据，但缺乏用于分层其严重程度的此类诊断工具。银屑病是一种皮肤、指甲和关节的慢性炎症性疾病。皮肤镜检查是一种用于诊断和评估银屑病严重程度的新诊断工具。本研究的主要目的是评估皮肤镜检查联合高迁移率族蛋白 B1（HMGB-1）血清水平在银屑病严重程度的诊断和分层中的价值。
本研究纳入了 60 名埃及人，分为两组，即银屑病患者和对照组。所有患者首先接受皮肤镜检查，然后评估所有研究组的 HMGB-1 血清水平。
银屑病患者的 HMGB-1 水平高于对照组。HMGB-1 血清水平在患者和对照组之间存在显著差异。HMGB-1 与疾病严重程度的不同阶段之间也存在正显著相关性。HMGB-1 与特定的皮肤镜发现（如血管模式和血管数量、红斑等级以及鳞屑类型（细、粗）和（细、厚））之间也存在显著相关性。
皮肤镜检查和 HMGB-1 可以被视为评估银屑病严重程度的一种新型联合诊断工具。
