Department of Gynecology of Traditional Chinese Medicine, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan, China.
Department of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
PLoS One. 2022 Sep 2;17(9):e0273561. doi: 10.1371/journal.pone.0273561. eCollection 2022.
Approximately 80% of children, adolescents and young adults (CAYA) cancer patients are expected to fully recover and survive for five years or more. The reproductive health is a particular area of their concern. Evidence demonstrates that previous therapeutic treatments for cancer and comorbidities may have harmful effects on female fertility and delivery outcomes, which will significantly affect patient quality of life. However, these reports are heterogeneous. Therefore, the purpose of this study is to provide the up-to-date evidence on the risk of adverse obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer.
This meta-analysis will be carried out and reported with adherence to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Cochrane Handbook. We will search online databases including PubMed, Cochrane Library, and Embase from inception to August, 2022 to identify all relevant cohort studies examining the relationship between cancer and subsequent obstetric and perinatal outcomes. Data extraction from eligible studies will be conducted and crosschecked separately by two investigators using pre-tested standardized data extraction forms. Discrepancies will be resolved via a third investigator. Methodological quality assessment for each study will be conducted using the Newcastle-Ottawa scale (NOS) tool. We will apply the DerSimonian-Laird random-effects model to calculate the pooled estimates. Further sources of heterogeneity will be explored by performing subgroup analysis based on multiple study characteristics. Potential publication bias will be assessed by inspection of a funnel plot, Begg's and Egger's regression tests of funnel plot asymmetry.
Ethical approval will not be required as all data used for this pooled analysis will be obtained from published cohort studies. The results of this study will be disseminated in a peer-reviewed journal and conference presentation.
DOI 10.17605/OSF.IO/K6QBG.
约 80%的儿童、青少年和青年癌症患者（CAYA）预计能够完全康复并存活五年或以上。他们特别关注生殖健康。有证据表明，先前的癌症治疗和合并症可能对女性生育能力和分娩结果产生有害影响，这将显著影响患者的生活质量。然而，这些报告存在异质性。因此，本研究的目的是提供关于儿童或青少年癌症女性幸存者不良产科和围产结局风险的最新证据。
本荟萃分析将按照观察性研究荟萃分析的流行病学（MOOSE）指南和 Cochrane 手册进行，并报告。我们将从建库到 2022 年 8 月，在在线数据库中搜索包括 PubMed、Cochrane 图书馆和 Embase 在内的所有相关队列研究，以确定评估癌症与随后的产科和围产结局之间关系的研究。将由两名研究人员使用预先测试的标准化数据提取表分别对合格研究进行数据提取和交叉核对。分歧将由第三名研究人员解决。将使用 Newcastle-Ottawa 量表（NOS）工具对每项研究的方法学质量进行评估。我们将应用 DerSimonian-Laird 随机效应模型来计算汇总估计值。将通过基于多项研究特征进行亚组分析来探索异质性的其他来源。通过检查漏斗图、Begg 和 Egger 回归检验漏斗图不对称性来评估潜在的发表偏倚。
由于本荟萃分析中使用的所有数据均来自已发表的队列研究，因此不需要伦理批准。本研究的结果将在同行评议的期刊和会议报告中发表。
OSF 注册号：DOI 10.17605/OSF.IO/K6QBG。
