Department of acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
PLoS One. 2023 Jun 29;18(6):e0287852. doi: 10.1371/journal.pone.0287852. eCollection 2023.
According to several studies, a specific dietary pattern can reduce the risk of dementia and cognitive impairment. However, the robustness of these results has not been tested. The study intends to investigate the association between nutrition intake and cognitive impairment in middle-aged and older adults (≥45-years) and provide reliable, evidence-based references for healthcare decision-makers, researchers, and policymakers.
Are the dietary characteristics of community-dwelling adults (≥45-years) associated with the occurrence of cognitive impairment?
The primary objective of this protocol is to synthesize the longitudinal observational evidence on the relationship between nutrition intake patterns and the incidence of cognitive impairment in middle-aged and older adults (≥45-years), and to provide detailed dietary recommendations for the prevention of cognitive impairment in this population.
Cohort studies conducted among adults (≥45-years) will be included. The following electronic databases will be searched for relevant records published by July 2023, with a restriction on language to English: Pubmed, Medline, Embase, Web of science, Cochrane Library. The studies will be selected, the data will be extracted, and the bias risk will be assessed by two independent investigators. The Meta-analysis of Observational Studies in Epidemiology guidelines will be followed to summarize observational studies, and the protocol will adhere to the recommendations from the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement. Endnote X9 will be used to manage data screening. We will use Review Manager 5.4 and Stata 16.0 to conduct data analysis, and a random-effects model will be applied to pool clinically homogenous studies. The results will be presented based on the form of nutrition intake. For assessing publication bias, Egger's test and visual inspection of funnel plots will be utilized.
As this study does not involve primary data, ethical approval is not required. The final report will be published in a peer-reviewed journal.
A registration number of DOI 10.17605/OSF.IO/NAKC3 was assigned to it on October 15, 2022 on Prospero.
根据多项研究，特定的饮食模式可降低痴呆和认知障碍的风险。然而，这些结果的稳健性尚未得到检验。本研究旨在调查中年和老年人（≥45 岁）的营养摄入与认知障碍之间的关联，并为医疗保健决策者、研究人员和政策制定者提供可靠的循证参考。
社区居住成年人（≥45 岁）的饮食特点是否与认知障碍的发生有关？
本方案的主要目的是综合观察性纵向研究证据，探讨中年和老年人（≥45 岁）营养摄入模式与认知障碍发生之间的关系，并为该人群预防认知障碍提供详细的饮食建议。
将纳入针对成年人（≥45 岁）进行的队列研究。将检索以下电子数据库中截至 2023 年 7 月发表的相关记录，语言限制为英语：Pubmed、Medline、Embase、Web of science、Cochrane Library。将由两名独立研究者进行研究选择、数据提取和偏倚风险评估。将遵循《观察性研究的荟萃分析流行病学指南》总结观察性研究，并按照《系统评价和荟萃分析报告的首选条目 2015 声明》的建议制定方案。将使用 Endnote X9 管理数据筛选。我们将使用 Review Manager 5.4 和 Stata 16.0 进行数据分析，并应用随机效应模型对具有临床同质性的研究进行汇总。结果将根据营养摄入形式呈现。为了评估发表偏倚，将使用 Egger 检验和漏斗图的视觉检查。
由于本研究不涉及原始数据，因此不需要伦理批准。最终报告将发表在同行评议的期刊上。
PROSPERO 注册号：2022 年 10 月 15 日在 Prospero 上为其分配了注册号 DOI 10.17605/OSF.IO/NAKC3。
