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70 岁及以上老年男性行人工尿控括约肌手术安全有效吗?

Is artificial urinary sphincter surgery safe and effective in elderly males aged 70 years and above?

机构信息

AndroUrology Centre, Brisbane, Australia.

University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.

出版信息

Low Urin Tract Symptoms. 2022 Nov;14(6):416-420. doi: 10.1111/luts.12460. Epub 2022 Aug 24.

Abstract

OBJECTIVES

To evaluate the clinical outcomes and patient satisfaction rate between men aged under and over 70 years who underwent artificial urinary sphincter (AUS) surgery.

METHODS

A prospective review of all men who received AUS between January 2008 and January 2018 was undertaken with a minimum 24-month review. All patient demographics and surgical outcomes including data on the Incontinence Impact Questionnaire, Patient Global Impression of Improvement (PGI-I) and National Surgical Quality Improvement Program Frailty Index (NSQIP-FI) scores, as well as patient satisfaction rates, were recorded.

RESULTS

Of the 245 AUS implanted, 60 patients were aged ≥70 years with 45 virgin cases and 15 revision AUS. Reduction in mean pad use and weight over 24 hours were significant at 0.21 (0-1) pads and 8 (0-30) g in both groups with no significant difference (P = 0.76). Kaplan-Meier estimates of AUS survival showed no significant difference between men aged ≥ and <70 years at 1 year (98% versus 96%; P = 0.44). The multivariate logistic regression model showed that radiation (adjusted odds ratio [OR] 3.8, 95% CI 1.4-6.8; P < 0.01) was a significant predictor of AUS revision, while age ≥ 70 years (adjusted OR 1.0, 95% CI 0.8-8.8; P = 0.14) and frailty (NSQIP-FI ≥ 0.27 adjusted OR 0.9, 95% CI 0.2-7.6; P = 0.82) were not. There were no significant differences in PGI-I scores (P = 0.43) and overall satisfaction rate (83% versus 84%; P = 0.44) between the two groups.

CONCLUSIONS

Men aged ≥70 years reported similar clinical efficacy as men aged <70 years in terms of device survival and satisfaction rates following AUS surgery.

摘要

目的

评估年龄在 70 岁以下和 70 岁以上的男性接受人工尿失禁括约肌(AUS)手术的临床结果和患者满意度。

方法

对 2008 年 1 月至 2018 年 1 月期间接受 AUS 手术的所有男性进行前瞻性回顾,随访时间至少为 24 个月。记录所有患者的人口统计学数据和手术结果,包括失禁影响问卷、患者整体改善印象(PGI-I)和国家手术质量改进计划脆弱指数(NSQIP-FI)评分,以及患者满意度。

结果

在植入的 245 个 AUS 中,有 60 名患者年龄≥70 岁,其中 45 名是初治患者,15 名是 AUS 翻修患者。两组患者的平均尿垫使用量和 24 小时体重减轻均有显著差异,分别为 0.21(0-1)个尿垫和 8(0-30)g,差异无统计学意义(P=0.76)。AUS 生存的 Kaplan-Meier 估计显示,年龄≥70 岁和<70 岁的男性在 1 年时的 AUS 存活率无显著差异(98%与 96%;P=0.44)。多变量逻辑回归模型显示,放疗(调整后的优势比[OR]3.8,95%CI 1.4-6.8;P<0.01)是 AUS 翻修的显著预测因素,而年龄≥70 岁(调整后的 OR 1.0,95%CI 0.8-8.8;P=0.14)和虚弱(NSQIP-FI≥0.27 调整后的 OR 0.9,95%CI 0.2-7.6;P=0.82)则不是。两组患者的 PGI-I 评分(P=0.43)和总体满意度(83%与 84%;P=0.44)无显著差异。

结论

在 AUS 手术后,年龄≥70 岁的男性在设备生存率和满意度方面与年龄<70 岁的男性报告了相似的临床疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a35/9804846/5ba1ad10e3a8/LUTS-14-416-g002.jpg

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