Inselspital Head and Neck Anticancer Center, Bern University Hospital, Bern, Switzerland.
Department of ENT, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Laryngoscope. 2023 Jul;133(7):1630-1637. doi: 10.1002/lary.30340. Epub 2022 Aug 22.
Fear of recurrence (FoR) affects the quality of life of head and neck cancer survivors. Identification of factors predisposing to FoR may help to recognize and treat patients at risk.
For this exploratory study, 101 disease-free head and neck cancer survivors completed a cross-sectional survey in 2017 that included the FoR questionnaire at a random point in time during their follow-up. Additionally, the patients were asked to choose their favorite among four follow-up schedules with or without systematic imaging and varying frequency of visits.
Elevated FoR was present in 36.6% of patients. Females and patients ≤65 years showed significantly higher FoR overall scores than males (score difference 3.40; CI 0.49-6.32; p = 0.022) and patients >65 years (score difference 4.25; CI 1.58-6.92; p = 0.002). A history of cancer recurrence or second primary malignancy increased the relative risk (RR) for elevated FoR (RR 1.7; CI 1.01-2.86; p = 0.046). Tumor stage and treatment modality were not significantly associated with elevated FoR or FoR overall score. Higher FoR overall scores were recorded in patients who favored intensive follow-up plans (mean overall FoR score 18 vs. 15; SD 7.7; p = 0.076) and systematic imaging in follow-up (17 vs. 13, SD 7.1; p = 0.034).
Fear of recurrence in head and neck cancer patients is associated with female sex, younger age, and history of a past recurrence or second primary malignancy. Due to its high prevalence, it should be addressed in clinical practice and future research.
NA Laryngoscope, 133:1630-1637, 2023.
复发恐惧（Fear of recurrence，FoR）会影响头颈部癌症幸存者的生活质量。识别导致 FoR 的因素有助于识别和治疗处于风险中的患者。
在这项探索性研究中，101 名无疾病头颈部癌症幸存者于 2017 年完成了一项横断面调查，在随访期间的任意时间点使用 FoR 问卷进行调查。此外，患者被要求从四种随访计划中选择他们最喜欢的一种，这些计划包括有或没有系统影像学检查以及不同的就诊频率。
36.6%的患者存在 FoR 升高。女性和≤65 岁的患者 FoR 总分明显高于男性（评分差异 3.40；CI 0.49-6.32；p=0.022）和>65 岁的患者（评分差异 4.25；CI 1.58-6.92；p=0.002）。癌症复发或第二原发恶性肿瘤史增加了 FoR 升高的相对风险（RR 1.7；CI 1.01-2.86；p=0.046）。肿瘤分期和治疗方式与 FoR 升高或 FoR 总分无显著相关性。在偏好强化随访计划（总 FoR 评分 18 分比 15 分；SD 7.7；p=0.076）和随访中进行系统影像学检查（17 分比 13 分，SD 7.1；p=0.034）的患者中，FoR 总分更高。
头颈部癌症患者的 FoR 与女性、年龄较小、既往复发或第二原发恶性肿瘤史有关。由于其高患病率，应在临床实践和未来研究中予以解决。
无。Laryngoscope, 133:1630-1637, 2023.
