Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada.
Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada; Gerontology Research Centre, Simon Fraser University, Vancouver, BC, Canada.
Maturitas. 2022 Dec;166:41-49. doi: 10.1016/j.maturitas.2022.08.007. Epub 2022 Aug 27.
Physical activity (PA) and total sleep time (TST) are each associated with cognition; however, whether these relationships vary by age and biological sex is unclear. We examined the relationships of PA or TST with cognition, and whether age and sex moderated these relationships, using baseline data from the Canadian Longitudinal Study on Aging (CLSA; 2010-2015).
A cross-sectional analysis of participants from the Comprehensive cohort of the CLSA with complete PA and sleep data (n = 20,307; age range 45-86 years).
PA and TST were measured using the Physical Activity Scale for the Elderly (PASE) and self-reported TST over the past month. Cognition was indexed using a three-factor structural equation model (i.e., memory, executive function, and verbal fluency).
Non-linear restricted cubic spline models indicated that PA and TST explained statistically significant (p < 0.01) but modest variance of each cognitive domain (<1 % of 23-24 % variance). Age and sex did not moderate associations of PA with any cognitive domain. However, age and sex moderated relationships of TST with cognition, whereby: 1) associations of TST with memory decreased with age for males and females; and 2) males and females had different age-associated relationships of TST with executive function and verbal fluency.
PA and TST modestly contribute to multiple domains of cognition across middle and older adulthood. Importantly, the association of PA with cognition does not appear to vary across middle or older adulthood, nor does it vary by biological sex; however, TST appears to have a complex relationship with multiple domains of cognition which is both age- and sex-dependent.
体力活动（PA）和总睡眠时间（TST）均与认知能力有关；然而，这些关系是否因年龄和性别而异尚不清楚。我们使用加拿大老龄化纵向研究（CLSA；2010-2015 年）的基线数据，研究了 PA 或 TST 与认知的关系，以及年龄和性别是否调节了这些关系。
对 CLSA 综合队列中具有完整 PA 和睡眠数据的参与者（n=20307；年龄范围 45-86 岁）进行的横断面分析。
使用老年人体力活动量表（PASE）和过去一个月的自我报告 TST 测量 PA 和 TST。认知功能由三因素结构方程模型（即记忆、执行功能和言语流畅性）来表示。
非线性限制立方样条模型表明，PA 和 TST 分别解释了记忆、执行功能和言语流畅性这三个认知领域具有统计学意义（p<0.01）但适度的变异（<1%，占 23-24%的变异）。年龄和性别并未调节 PA 与任何认知领域之间的关系。然而，年龄和性别调节了 TST 与认知的关系，具体表现为：1）TST 与记忆的关联随年龄增长而下降，无论男女；2）男性和女性的 TST 与执行功能和言语流畅性的年龄相关性不同。
PA 和 TST 对中年和老年期多个认知领域有适度贡献。重要的是，PA 与认知的关联在中年或老年期似乎没有变化，也不受生物学性别影响；然而，TST 与多个认知领域的关系似乎较为复杂，既依赖于年龄，也依赖于性别。
