SLC4A7 和 mTORC1 通过碳酸氢盐提高核苷酸合成。
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate.
机构信息
Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC, Canada.
出版信息
Mol Cell. 2022 Sep 1;82(17):3121-3123. doi: 10.1016/j.molcel.2022.08.010.
PMID:36055205
Abstract
In this issue of Molecular Cell, Ali et al. (2022) show that bicarbonate uptake by SLC4A7 fuels de novo nucleotide synthesis and cell proliferation and is regulated by mTORC1.
摘要
在本期《分子细胞》中，Ali 等人（2022 年）表明，SLC4A7 通过摄取重碳酸盐为从头合成核苷酸和细胞增殖提供动力，并且受 mTORC1 的调控。
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