State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, School of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315211, Zhejiang, P. R. China.
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R. China.
J Dairy Sci. 2022 Oct;105(10):7865-7877. doi: 10.3168/jds.2022-21877. Epub 2022 Aug 31.
The by-products of milk fermentation by lactic acid bacteria provide potential health benefits to the balance of host intestinal microflora. In this study, the anti-inflammatory properties of fatty acids from monoculture-strain (Lactiplantibacillusplantarum A3) and multiple-strain (Streptococcus thermophilus, Lactobacillus bulgaricus, and L. plantarum A3 1:1:2) fermented milk were evaluated in a mouse model of dextran sulfate sodium-induced colitis, and the gut microbiota regulation properties of the fatty acids were also investigated. Results showed that fatty acids can attenuate the inflammatory response by inhibiting the expression of inflammatory factors IL-6 and tumor necrosis factor-α, and blocking the phosphorylation of the JNK in MAPK signal pathway. In addition, the relative abundance of the taxa Akkermansia and Lactobacillus were both enriched after the fatty acid intervention. This finding suggests that fatty acids from the milk fermentation with mixed lactic acid bacteria starters can reduce the severity of dextran sulfate sodium-induced colitis and enhance the abundance of the probiotics in the mice intestinal tract.
乳酸菌发酵牛奶的副产物为宿主肠道微生物菌群的平衡提供了潜在的健康益处。在这项研究中，我们评估了单菌株（植物乳杆菌 A3）和多菌株（嗜热链球菌、保加利亚乳杆菌和植物乳杆菌 A3 1:1:2）发酵乳中的脂肪酸在葡聚糖硫酸钠诱导的结肠炎小鼠模型中的抗炎特性，并研究了脂肪酸对肠道微生物群的调节特性。结果表明，脂肪酸可以通过抑制炎症因子 IL-6 和肿瘤坏死因子-α 的表达以及阻断 MAPK 信号通路中 JNK 的磷酸化来减轻炎症反应。此外，在脂肪酸干预后，Akkermansia 和乳杆菌的分类群丰度都得到了富集。这一发现表明，混合乳酸菌发酵乳中的脂肪酸可以降低葡聚糖硫酸钠诱导的结肠炎的严重程度，并增强小鼠肠道内益生菌的丰度。
