Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010010, China.
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010010, China; Camel Research Institute of Inner Mongolia, Alashan, Inner Mongolia, 750330, China.
J Dairy Sci. 2022 May;105(5):3782-3793. doi: 10.3168/jds.2021-21345. Epub 2022 Mar 2.
Camel milk is a nutritionally rich food that shows anti-inflammatory, immune regulation, and gut microbiota maintenance properties. However, the relationship between camel milk and the intestinal microbiota during colitis is unclear. Herein, we evaluated the protective effect of camel milk in mice with colitis induced using dextran sodium sulfate. Our results showed that camel milk can prevent body weight loss and colon shortening, reduce the disease activity index, and attenuate colon tissue damage. Additionally, camel milk could reduce the overexpression of inflammatory factors, inhibit the apoptosis of intestinal epithelial cells, and promote the expression of claudin-1, occludin, and zonula occludens-1 proteins. Moreover, camel milk effectively regulated intestinal microbiota in mice with colitis by increasing the gut microbiota diversity, increasing the abundance of beneficial bacteria (such as g_norank_f_Muribaculaceae, and Lachnospiraceae_NK4A136_group), and reducing the number of harmful bacteria (Bacteroides, Escherichia-Shigella). In addition, camel milk increased the levels of intestinal short-chain fatty acids. The results of the present study demonstrated that via regulating the intestinal microbiota, maintaining intestinal barrier function, and inhibiting proinflammatory cytokines, camel milk can ameliorate dextran sodium sulfate-induced colitis.
骆驼奶是一种营养丰富的食物，具有抗炎、免疫调节和维持肠道微生物群的特性。然而，骆驼奶与结肠炎期间肠道微生物群的关系尚不清楚。在此，我们评估了骆驼奶在葡聚糖硫酸钠诱导的结肠炎小鼠中的保护作用。我们的结果表明，骆驼奶可以预防体重减轻和结肠缩短，降低疾病活动指数，并减轻结肠组织损伤。此外，骆驼奶可以减少炎症因子的过度表达，抑制肠上皮细胞凋亡，并促进 Claudin-1、Occludin 和 Zonula Occludens-1 蛋白的表达。此外，骆驼奶通过增加肠道微生物多样性、增加有益菌（如 g_norank_f_Muribaculaceae 和 Lachnospiraceae_NK4A136_group）的丰度和减少有害菌（Bacteroides、Escherichia-Shigella）的数量，有效调节了结肠炎小鼠的肠道微生物群。此外，骆驼奶增加了肠道短链脂肪酸的水平。本研究结果表明，骆驼奶通过调节肠道微生物群、维持肠道屏障功能和抑制促炎细胞因子，可改善葡聚糖硫酸钠诱导的结肠炎。
