Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, Avenida de Roma, s/n, 33011, Oviedo, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
Eur Arch Otorhinolaryngol. 2023 Feb;280(2):829-837. doi: 10.1007/s00405-022-07622-1. Epub 2022 Sep 3.
Surgical resection or radiotherapy (RT) are standard approaches for early-staged hypopharyngeal squamous cell carcinoma (HPSCC). Transoral laser microsurgery (TOLMS) seems to provide good oncological and functional results with few local complications. The aim of our study was to analyze the outcomes of TOLMS, with or without neck dissection or RT, in the treatment of HPSCC in a tertiary referral center.
A retrospective study was conducted in patients with early T-category (T1-T2) HPSCC treated by TOLMS.
A total of 34 patients were included in the study. The series includes 17 (50%) T1 and 17 (50%) T2 classified tumors. The 5-year overall survival and disease-specific survival rates were 51% and 66%, respectively, with a 5-year local control rate of 92%. All patients reassumed oral diet and none of them had a tracheostomy at the end of the follow-up.
TOLMS offers an effective treatment option in terms of oncologic control and function preservation in locally circumscribed HPSCC.
手术切除或放射治疗（RT）是早期下咽鳞状细胞癌（HPSCC）的标准治疗方法。经口激光微创手术（TOLMS）似乎可以提供良好的肿瘤学和功能结果，且局部并发症较少。我们的研究目的是分析在三级转诊中心，TOLMS 联合或不联合颈清扫术或 RT 治疗 HPSCC 的结果。
对经 TOLMS 治疗的早期 T 分期（T1-T2）HPSCC 患者进行回顾性研究。
本研究共纳入 34 例患者。该系列包括 17 例（50%）T1 期和 17 例（50%）T2 期肿瘤。5 年总生存率和疾病特异性生存率分别为 51%和 66%，5 年局部控制率为 92%。所有患者在随访结束时均恢复经口进食，且均无需行气管造口术。
TOLMS 为局部局限性 HPSCC 的肿瘤控制和功能保留提供了一种有效的治疗选择。
