C-反应蛋白能否预测非体外循环冠状动脉旁路移植术的凝血情况？一项队列研究。
Can C-reactive protein predict coagulation in off pump coronary artery bypass grafting? A cohort study.
机构信息
Department of Anestheiology, the Affiliated Hospital of Qingdao University, No. 59, Haier Road, Qingdao, Shandong province, China.
Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
出版信息
J Cardiothorac Surg. 2022 Sep 2;17(1):225. doi: 10.1186/s13019-022-01949-w.
BACKGROUND
Previous study found that C-reactive protein (CRP) can predict bleeding after on-pump CABG. To evaluate whether preoperative C-reactive protein (CRP) can be a novel marker of postoperative bleeding in patients having off-pump coronary artery bypass grafting (CABG).
METHODS
This is a retrospective cohort study. Multiple variable regression analyses were performed. 537 patients undergoing off-pump isolated primary CABG at Fuwai Hospital from September 2017 to July 2018 were recorded. The primary endpoint was bleeding volume within 24 h after surgery.
RESULTS
Data of 537 patients undergoing off-pump isolated primary CABG at Fuwai Hospital were recorded. The correlations between bleeding volume within 24 h after surgery and preoperative data were analyzed with univariate and multivariate linear regression. Much more preoperative CRP concentration (B = -0.089, P < 0.05) was associated with less postoperative bleeding volume and fibrinogen (B = 0.594, p < 0.001).
CONCLUSIONS
Preoperative CRP concentration is independently correlated with the postoperative volume of bleeding within 24 h. CRP may become a novel coagulation index in coronary artery atherosclerotic disease.
背景
先前的研究发现 C 反应蛋白（CRP）可预测体外循环冠状动脉旁路移植术（CABG）后的出血情况。本研究旨在评估术前 C 反应蛋白（CRP）是否可以作为体外循环冠状动脉旁路移植术（CABG）患者术后出血的新型标志物。
方法
本研究为回顾性队列研究。进行了多变量回归分析。记录了 2017 年 9 月至 2018 年 7 月在阜外医院行非体外循环单纯冠状动脉旁路移植术的 537 例患者的数据。主要终点为术后 24 小时内的出血量。
结果
记录了 537 例在阜外医院行非体外循环单纯冠状动脉旁路移植术的患者的数据。使用单因素和多因素线性回归分析了术后 24 小时内出血量与术前数据之间的相关性。术前 CRP 浓度（B=-0.089，P<0.05）与术后出血量和纤维蛋白原（B=0.594，P<0.001）呈负相关。
结论
术前 CRP 浓度与术后 24 小时内出血量独立相关。CRP 可能成为冠状动脉粥样硬化性疾病的新型凝血指标。
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