Stav Michael, Matatov Yuri, Hoffmann Dana, Heesen Philip, Gliesche Vincent, Binyamin Yair, Ioscovich Alexander, Eidelman Leonid A, Orbach-Zinger Sharon
Department of Anaesthesia, Beilinson Hospital, Petach Tikvah, and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.
University of Zurich, Zurich, Switzerland.
Acta Anaesthesiol Scand. 2023 Jan;67(1):29-35. doi: 10.1111/aas.14146. Epub 2022 Sep 11.
Conversion from spinal anaesthesia to general anaesthesia (GA) was shown to be associated with more complications. It has been postulated that spinal injection of a low dose of local anaesthetic is a risk factor. We aimed to discover the rate of conversion from spinal anaesthesia to GA in women who received at least 10 mg heavy bupivacaine and opioids and assess its risk factors.
All women that underwent spinal anaesthesia for caesarean section from 1 January 2017 to 31 December 2020 were included in this analysis. Spinal anaesthesia was performed according to department protocol using heavy bupivacaine 0.5% 10-13 mg, fentanyl 20 μg, and morphine 0.1 mg. We examined rate of conversion from spinal anaesthesia to GA and rate of need for analgesia/sedation.
There were 1.7% of women that required conversion to GA. Bupivacaine dose (OR 0.54 [95% CI 0.38 to 0.75], p < 0.001), surgery time (OR 1.03 [95% CI 1.02 to 1.04], p < 0.001), emergency caesarean section (OR 1.06 [95% CI 1.16 to 3.76], p = 0.015), and postpartum haemorrhage (OR 5.96 [95% CI 1.09 to 25.18], p = 0.025) were independent predictors of need for conversion to GA. Of the women who had CS under spinal anaesthesia, 4.1% of parturients required intraoperative analgesics/sedatives and 9.1% required anxiolysis.
A small proportion of women required conversion to GA. This conversion occurred especially with emergency caesarean section and when low spinal bupivacaine doses were used.
脊髓麻醉转换为全身麻醉(GA)与更多并发症相关。据推测,脊髓注射低剂量局部麻醉剂是一个危险因素。我们旨在发现接受至少10毫克重比重布比卡因和阿片类药物的女性中脊髓麻醉转换为GA的发生率,并评估其危险因素。
纳入2017年1月1日至2020年12月31日期间接受剖宫产脊髓麻醉的所有女性。根据科室方案,使用0.5%重比重布比卡因10 - 13毫克、芬太尼20微克和吗啡0.1毫克进行脊髓麻醉。我们检查了脊髓麻醉转换为GA的发生率以及镇痛/镇静需求率。
1.7%的女性需要转换为GA。布比卡因剂量(比值比[OR]0.54[95%置信区间(CI)0.38至0.75],p<0.001)、手术时间(OR 1.03[95%CI 1.02至1.04],p<0.001)、急诊剖宫产(OR 1.06[95%CI 1.16至3.76],p = 0.015)和产后出血(OR 5.96[95%CI 1.09至25.18],p = 0.025)均为转换为GA需求的独立预测因素。在接受脊髓麻醉下剖宫产的女性中,4.1%的产妇需要术中使用镇痛药/镇静剂,9.1%的产妇需要抗焦虑治疗。
一小部分女性需要转换为GA。这种转换尤其发生在急诊剖宫产以及使用低剂量脊髓布比卡因时。