Veering B T, Burm A G, van Kleef J W, Hennis P J, Spierdijk J
Anesth Analg. 1987 Jul;66(7):589-93.
Effects of aging after epidural administration of 0.5% bupivacaine without epinephrine were studied in two groups of patients, between 20 and 55 yr old and older than 55 yr, respectively. All patients received 95 mg bupivacaine HCl. The onset of analgesia in caudad segments decreased with age and the upper level of analgesia increased with age. Effects of age on duration of anesthesia could not be demonstrated. The total plasma clearance of bupivacaine decreased and the terminal half-life increased with age. Age had no effect on the peak plasma concentrations and time to peak concentrations.
分别在两组年龄在20至55岁之间以及55岁以上的患者中，研究了硬膜外给予不含肾上腺素的0.5%布比卡因后的衰老效应。所有患者均接受95毫克盐酸布比卡因。尾段镇痛起效时间随年龄增长而缩短，镇痛平面上限随年龄增长而升高。未证实年龄对麻醉持续时间有影响。布比卡因的血浆总清除率随年龄增长而降低，终末半衰期随年龄增长而延长。年龄对血浆峰值浓度及达峰时间无影响。
