McAuliffe J J, Hickey P R
Anesthesiology. 1987 Aug;67(2):231-5. doi: 10.1097/00000542-198708000-00013.
The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellular pH mediated the effects of halothane. Steady-state HEP concentrations and intracellular pH were unaffected, despite profound reductions of mechanical performance. The data also suggest that halothane, in the concentrations studied, does not cause significant uncoupling of oxidative phosphorylation.
新生儿心脏对氟烷引起的心脏抑制尤为敏感。这种敏感性的原因尚不确定。使用31P核磁共振研究了离体、灌注、等容收缩的新生兔心脏，以确定高能磷酸盐（HEP）浓度或细胞内pH值的变化是否介导了氟烷的作用。尽管机械性能大幅下降，但稳态HEP浓度和细胞内pH值并未受到影响。数据还表明，在所研究的浓度下，氟烷不会导致氧化磷酸化的显著解偶联。
